Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer

Research output: Contribution to journalReview article

660 Scopus citations

Abstract

Several decades of research have sought to characterize tumor cell metabolism in the hope that tumor-specific activities can be exploited to treat cancer. Having originated from Warburg's seminal observation of aerobic glycolysis in tumor cells, most of this attention has focused on glucose metabolism. However, since the 1950s cancer biologists have also recognized the importance of glutamine (Q) as a tumor nutrient. Glutamine contributes to essentially every core metabolic task of proliferating tumor cells: it participates in bioenergetics, supports cell defenses against oxidative stress and complements glucose metabolism in the production of macromolecules. The interest in glutamine metabolism has been heightened further by the recent findings that c-myc controls glutamine uptake and degradation, and that glutamine itself exerts influence over a number of signaling pathways that contribute to tumor growth. These observations are stimulating a renewed effort to understand the regulation of glutamine metabolism in tumors and to develop strategies to target glutamine metabolism in cancer. In this study we review the protean roles of glutamine in cancer, both in the direct support of tumor growth and in mediating some of the complex effects on whole-body metabolism that are characteristic of tumor progression.

Original languageEnglish (US)
Pages (from-to)313-324
Number of pages12
JournalOncogene
Volume29
Issue number3
DOIs
StatePublished - Jan 1 2010

Keywords

  • Cachexia
  • Cancer
  • Glutamine
  • Metabolism
  • Warburg effect

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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