Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency

Robert R. Edelman, Bettina Siewert, David G. Darby, Venketasen Thangaraj, Anna C. Nobre, M. Marsel Mesulam, Steven Warach

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To create qualitative maps of cerebral blood flow (CBF) with the EPISTAR (echo-planar imaging and signal targeting with alternating radio frequency) technique. MATERIALS AND METHODS: The EPISTAR technique was performed in a pig model of hypercapnia and then tested in 26 volunteers by using various paradigms for cortical activation. Echo-planar images were acquired with and without use of a radio-frequency inversion pulse applied to inflowing arterial spins. A qualitative map of CBF was then created by subtracting the image obtained without the radio-frequency pulse from that obtained with the radio-frequency pulse. RESULTS: Progressively more distal portions of the tagged vessels were seen as the inflow time was lengthened until cortical enhancement was seen for inflow times of approximately 1 second or longer. Signal intensity increases from rest to sensorimotor activation ranged from 13% to 193%. CBF changes in the motor strip, primary visual cortex, and the motor area for eye movements were well localized to the cortical gray matter ribbon. CONCLUSION: The EPISTAR technique is a rapid, noninvasive means for creating qualitative maps of CBF.

Original languageEnglish (US)
Pages (from-to)513-520
Number of pages8
JournalRadiology
Volume192
Issue number2
StatePublished - Aug 1994

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Cerebrovascular Circulation
Echo-Planar Imaging
Radio
Motor Cortex
Hypercapnia
Visual Cortex
Eye Movements
Volunteers
Swine

Keywords

  • Cerebral blood vessels, flow dynamics
  • Magnetic resonance (MR), echo- planar
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Edelman, R. R., Siewert, B., Darby, D. G., Thangaraj, V., Nobre, A. C., Mesulam, M. M., & Warach, S. (1994). Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. Radiology, 192(2), 513-520.

Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. / Edelman, Robert R.; Siewert, Bettina; Darby, David G.; Thangaraj, Venketasen; Nobre, Anna C.; Mesulam, M. Marsel; Warach, Steven.

In: Radiology, Vol. 192, No. 2, 08.1994, p. 513-520.

Research output: Contribution to journalArticle

Edelman, RR, Siewert, B, Darby, DG, Thangaraj, V, Nobre, AC, Mesulam, MM & Warach, S 1994, 'Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency', Radiology, vol. 192, no. 2, pp. 513-520.
Edelman, Robert R. ; Siewert, Bettina ; Darby, David G. ; Thangaraj, Venketasen ; Nobre, Anna C. ; Mesulam, M. Marsel ; Warach, Steven. / Qualitative mapping of cerebral blood flow and functional localization with echo-planar MR imaging and signal targeting with alternating radio frequency. In: Radiology. 1994 ; Vol. 192, No. 2. pp. 513-520.
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