Quality of life and everyday activities in patients with primary biliary cirrhosis

Carlo Selmi, M. Eric Gershwin, Keith D. Lindor, Howard J. Worman, Ellen B. Gold, Mitchell Watnik, Jessica Utts, Pietro Invernizzi, Marshall M. Kaplan, John M. Vierling, Christopher L. Bowlus, Marina G. Silveira, Ilaria Bossi, Fred Askari, Nancy Bach, Nathan Bass, Gordon D. Benson, Andres Blei, Andrea D. Branch, Thomas Capozza & 19 others David J. Clain, Robert Gish, Richard Green, M. Edwyn Harrison, Steven Herrine, Emmet B. Keeffe, Natasha Khazai, Kris V. Kowdley, Edward L. Krawitt, John Lake, Douglas LaBrecque, Velimir Luketic, Andrew Mason, Marlyn J. Mayo, Timothy McCashland, Santiago Munoz, Paul Pockros, Don Rockey, Alastair D. Smith

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Primary biliary cirrhosis (PBC) is generally a slowly progressive disease that may lead to cirrhosis and liver failure. However, patients with PBC often suffer from a variety of symptoms long before the development of cirrhosis that include issues of daily living that have an impact on their work environment and their individual quality of life. We therefore examined multiple parameters by taking advantage of the database of our cohort of 1032 patients with PBC and 1041 matched controls. The data were obtained from patients from 23 tertiary referral centers throughout the United States and from rigorously matched controls by age, sex, ethnicity, and random-digit dialing. The data showed that patients with PBC were more likely than controls to have significant articular symptoms, a reduced ability to perform household chores, and the need for help with routine activities. Patients with PBC rated their overall activity similar or superior to that of controls; however, more of them reported limitations in their ability to carry out activities at work or at home and difficulties in everyday activities. PBC cases also more frequently reported limitations in participating in certain sports or exercises and pursuing various hobbies; however, they did not report significant limitations in social activities. In a multivariable analysis, household income, a diagnosis of systemic lupus erythematosus, limitations in work activities, a reduction in work secondary to disability, and church attendance were independently increased in PBC cases with respect to controls. Conclusion: Our data indicate that the quality of life of patients with PBC in the United States is generally well preserved. Nevertheless, patients with PBC suffer significantly more than controls from a variety of symptoms that are beyond the immediate impact of liver failure and affect their lifestyle, personal relationships, and work activities.

Original languageEnglish (US)
Pages (from-to)1836-1843
Number of pages8
JournalHepatology
Volume46
Issue number6
DOIs
StatePublished - Dec 2007

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Biliary Liver Cirrhosis
Quality of Life
Aptitude
Liver Failure
Fibrosis
Hobbies
Tertiary Care Centers
Systemic Lupus Erythematosus
Sports
Life Style
Joints
Databases
Exercise

ASJC Scopus subject areas

  • Hepatology

Cite this

Selmi, C., Gershwin, M. E., Lindor, K. D., Worman, H. J., Gold, E. B., Watnik, M., ... Smith, A. D. (2007). Quality of life and everyday activities in patients with primary biliary cirrhosis. Hepatology, 46(6), 1836-1843. https://doi.org/10.1002/hep.21953

Quality of life and everyday activities in patients with primary biliary cirrhosis. / Selmi, Carlo; Gershwin, M. Eric; Lindor, Keith D.; Worman, Howard J.; Gold, Ellen B.; Watnik, Mitchell; Utts, Jessica; Invernizzi, Pietro; Kaplan, Marshall M.; Vierling, John M.; Bowlus, Christopher L.; Silveira, Marina G.; Bossi, Ilaria; Askari, Fred; Bach, Nancy; Bass, Nathan; Benson, Gordon D.; Blei, Andres; Branch, Andrea D.; Capozza, Thomas; Clain, David J.; Gish, Robert; Green, Richard; Harrison, M. Edwyn; Herrine, Steven; Keeffe, Emmet B.; Khazai, Natasha; Kowdley, Kris V.; Krawitt, Edward L.; Lake, John; LaBrecque, Douglas; Luketic, Velimir; Mason, Andrew; Mayo, Marlyn J.; McCashland, Timothy; Munoz, Santiago; Pockros, Paul; Rockey, Don; Smith, Alastair D.

In: Hepatology, Vol. 46, No. 6, 12.2007, p. 1836-1843.

Research output: Contribution to journalArticle

Selmi, C, Gershwin, ME, Lindor, KD, Worman, HJ, Gold, EB, Watnik, M, Utts, J, Invernizzi, P, Kaplan, MM, Vierling, JM, Bowlus, CL, Silveira, MG, Bossi, I, Askari, F, Bach, N, Bass, N, Benson, GD, Blei, A, Branch, AD, Capozza, T, Clain, DJ, Gish, R, Green, R, Harrison, ME, Herrine, S, Keeffe, EB, Khazai, N, Kowdley, KV, Krawitt, EL, Lake, J, LaBrecque, D, Luketic, V, Mason, A, Mayo, MJ, McCashland, T, Munoz, S, Pockros, P, Rockey, D & Smith, AD 2007, 'Quality of life and everyday activities in patients with primary biliary cirrhosis', Hepatology, vol. 46, no. 6, pp. 1836-1843. https://doi.org/10.1002/hep.21953
Selmi C, Gershwin ME, Lindor KD, Worman HJ, Gold EB, Watnik M et al. Quality of life and everyday activities in patients with primary biliary cirrhosis. Hepatology. 2007 Dec;46(6):1836-1843. https://doi.org/10.1002/hep.21953
Selmi, Carlo ; Gershwin, M. Eric ; Lindor, Keith D. ; Worman, Howard J. ; Gold, Ellen B. ; Watnik, Mitchell ; Utts, Jessica ; Invernizzi, Pietro ; Kaplan, Marshall M. ; Vierling, John M. ; Bowlus, Christopher L. ; Silveira, Marina G. ; Bossi, Ilaria ; Askari, Fred ; Bach, Nancy ; Bass, Nathan ; Benson, Gordon D. ; Blei, Andres ; Branch, Andrea D. ; Capozza, Thomas ; Clain, David J. ; Gish, Robert ; Green, Richard ; Harrison, M. Edwyn ; Herrine, Steven ; Keeffe, Emmet B. ; Khazai, Natasha ; Kowdley, Kris V. ; Krawitt, Edward L. ; Lake, John ; LaBrecque, Douglas ; Luketic, Velimir ; Mason, Andrew ; Mayo, Marlyn J. ; McCashland, Timothy ; Munoz, Santiago ; Pockros, Paul ; Rockey, Don ; Smith, Alastair D. / Quality of life and everyday activities in patients with primary biliary cirrhosis. In: Hepatology. 2007 ; Vol. 46, No. 6. pp. 1836-1843.
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abstract = "Primary biliary cirrhosis (PBC) is generally a slowly progressive disease that may lead to cirrhosis and liver failure. However, patients with PBC often suffer from a variety of symptoms long before the development of cirrhosis that include issues of daily living that have an impact on their work environment and their individual quality of life. We therefore examined multiple parameters by taking advantage of the database of our cohort of 1032 patients with PBC and 1041 matched controls. The data were obtained from patients from 23 tertiary referral centers throughout the United States and from rigorously matched controls by age, sex, ethnicity, and random-digit dialing. The data showed that patients with PBC were more likely than controls to have significant articular symptoms, a reduced ability to perform household chores, and the need for help with routine activities. Patients with PBC rated their overall activity similar or superior to that of controls; however, more of them reported limitations in their ability to carry out activities at work or at home and difficulties in everyday activities. PBC cases also more frequently reported limitations in participating in certain sports or exercises and pursuing various hobbies; however, they did not report significant limitations in social activities. In a multivariable analysis, household income, a diagnosis of systemic lupus erythematosus, limitations in work activities, a reduction in work secondary to disability, and church attendance were independently increased in PBC cases with respect to controls. Conclusion: Our data indicate that the quality of life of patients with PBC in the United States is generally well preserved. Nevertheless, patients with PBC suffer significantly more than controls from a variety of symptoms that are beyond the immediate impact of liver failure and affect their lifestyle, personal relationships, and work activities.",
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AU - Selmi, Carlo

AU - Gershwin, M. Eric

AU - Lindor, Keith D.

AU - Worman, Howard J.

AU - Gold, Ellen B.

AU - Watnik, Mitchell

AU - Utts, Jessica

AU - Invernizzi, Pietro

AU - Kaplan, Marshall M.

AU - Vierling, John M.

AU - Bowlus, Christopher L.

AU - Silveira, Marina G.

AU - Bossi, Ilaria

AU - Askari, Fred

AU - Bach, Nancy

AU - Bass, Nathan

AU - Benson, Gordon D.

AU - Blei, Andres

AU - Branch, Andrea D.

AU - Capozza, Thomas

AU - Clain, David J.

AU - Gish, Robert

AU - Green, Richard

AU - Harrison, M. Edwyn

AU - Herrine, Steven

AU - Keeffe, Emmet B.

AU - Khazai, Natasha

AU - Kowdley, Kris V.

AU - Krawitt, Edward L.

AU - Lake, John

AU - LaBrecque, Douglas

AU - Luketic, Velimir

AU - Mason, Andrew

AU - Mayo, Marlyn J.

AU - McCashland, Timothy

AU - Munoz, Santiago

AU - Pockros, Paul

AU - Rockey, Don

AU - Smith, Alastair D.

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N2 - Primary biliary cirrhosis (PBC) is generally a slowly progressive disease that may lead to cirrhosis and liver failure. However, patients with PBC often suffer from a variety of symptoms long before the development of cirrhosis that include issues of daily living that have an impact on their work environment and their individual quality of life. We therefore examined multiple parameters by taking advantage of the database of our cohort of 1032 patients with PBC and 1041 matched controls. The data were obtained from patients from 23 tertiary referral centers throughout the United States and from rigorously matched controls by age, sex, ethnicity, and random-digit dialing. The data showed that patients with PBC were more likely than controls to have significant articular symptoms, a reduced ability to perform household chores, and the need for help with routine activities. Patients with PBC rated their overall activity similar or superior to that of controls; however, more of them reported limitations in their ability to carry out activities at work or at home and difficulties in everyday activities. PBC cases also more frequently reported limitations in participating in certain sports or exercises and pursuing various hobbies; however, they did not report significant limitations in social activities. In a multivariable analysis, household income, a diagnosis of systemic lupus erythematosus, limitations in work activities, a reduction in work secondary to disability, and church attendance were independently increased in PBC cases with respect to controls. Conclusion: Our data indicate that the quality of life of patients with PBC in the United States is generally well preserved. Nevertheless, patients with PBC suffer significantly more than controls from a variety of symptoms that are beyond the immediate impact of liver failure and affect their lifestyle, personal relationships, and work activities.

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