Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network

Kristin David; Kris V. Kowdley; Aynur Unalp; Fasiha Kanwal; Elizabeth M. Brunt; Jeffrey B. Schwimmer; Stephanie Abrams; Diana Arceo; Denise Espinosa; Leanel Fairly; Arthur McCullough; Diane Bringman; Srinivasan Dasarathy; Carol Hawkins; Yao Chang Liu; Nicholette Rogers; Margaret Stager; Kevin Edwards; Ruth Sargent; Melissa Coffey; Karen Murray; Melissa Young; Parvathi Mohan; Kavita Nair; Anna Mae Diehl; Marcia Gortfried; Cynthia Guy; Paul Killenberg; Samantha Kwan; Yi Ping Pan; Dawn Piercy; Melissa Smith; Prajakta Bhimalli; Naga Chalasani; Oscar W. Cummings; Lydia Lee; Linda Ragozzino; Raj Vuppalanchi; Ann Scheimann; Michael Torbenson; Ann Klipsch; Jean Molleston; Girish Subbarao; Sarah Barlow; Jose Derdoy; Joyce Hoffmann; Debra King; Joan Siegner; Susan Stewart; Brent A. Tetri; Judy Thompson; Cynthia Behling; Manual Celedon; Lisa Clark; Janis Durelle; Tarek Hassanein; Joel E. Lavine; Susana Mendoza; Claude Sirlin; Tanya Stein; Allison Tobin; Kiran Bambha; Nathan M. Bass; Linda D. Ferrell; Danuta Filipowski; Raphael Merriman; Mark Pabst; Monique Rosenthal; Philip Rosenthal; Tessa Steel; Sherry Boyett; Daphne Bryan; Melissa J. Contos; Michael Fuchs; Martin Graham; Amy Jones; Velimir A.C. Luketic; Bimalijit Sandhu; Arun J. Sanyal; Carol Sargeant; Kimberly Selph; Melanie White; Grace Gyurkey; Jody Mooney; James Nelson; Sarah Roberts; Cheryl Saunders; Alice Stead; Chia Wang; Matthew Yeh; Elizabeth Brunt; David Kleiner; Gilman D. Grave; Terry T.K. Huang; Edward Doo; James E. Everhart; Jay H. Hoofnagle; Patricia R. Robuck; Leonard Seeff; Patricia Belt; Fred Brancati; Jeanne Clark; Ryan Colvin; Michele Donithan; Mika Green; Rosemary Hollick; Milana Isaacson; Wana Kim; Alison Lydecker; Laura Miriel; Alice Sternberg; James Tonascia; Mark Van Natta; Laura Wilson; Katherine Yates

doi:10.1002/hep.22868

Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network

Kristin David, Kris V. Kowdley, Aynur Unalp, Fasiha Kanwal, Elizabeth M. Brunt, Jeffrey B. Schwimmer, Stephanie Abrams, Diana Arceo, Denise Espinosa, Leanel Fairly, Arthur McCullough, Diane Bringman, Srinivasan Dasarathy, Carol Hawkins, Yao Chang Liu, Nicholette Rogers, Margaret Stager, Kevin Edwards, Ruth Sargent, Melissa CoffeyKaren Murray, Melissa Young, Parvathi Mohan, Kavita Nair, Anna Mae Diehl, Marcia Gortfried, Cynthia Guy, Paul Killenberg, Samantha Kwan, Yi Ping Pan, Dawn Piercy, Melissa Smith, Prajakta Bhimalli, Naga Chalasani, Oscar W. Cummings, Lydia Lee, Linda Ragozzino, Raj Vuppalanchi, Ann Scheimann, Michael Torbenson, Ann Klipsch, Jean Molleston, Girish Subbarao, Sarah Barlow, Jose Derdoy, Joyce Hoffmann, Debra King, Joan Siegner, Susan Stewart, Brent A. Tetri, Judy Thompson, Cynthia Behling, Manual Celedon, Lisa Clark, Janis Durelle, Tarek Hassanein, Joel E. Lavine, Susana Mendoza, Claude Sirlin, Tanya Stein, Allison Tobin, Kiran Bambha, Nathan M. Bass, Linda D. Ferrell, Danuta Filipowski, Raphael Merriman, Mark Pabst, Monique Rosenthal, Philip Rosenthal, Tessa Steel, Sherry Boyett, Daphne Bryan, Melissa J. Contos, Michael Fuchs, Martin Graham, Amy Jones, Velimir A.C. Luketic, Bimalijit Sandhu, Arun J. Sanyal, Carol Sargeant, Kimberly Selph, Melanie White, Grace Gyurkey, Jody Mooney, James Nelson, Sarah Roberts, Cheryl Saunders, Alice Stead, Chia Wang, Matthew Yeh, Elizabeth Brunt, David Kleiner, Gilman D. Grave, Terry T.K. Huang, Edward Doo, James E. Everhart, Jay H. Hoofnagle, Patricia R. Robuck, Leonard Seeff, Patricia Belt, Fred Brancati, Jeanne Clark, Ryan Colvin, Michele Donithan, Mika Green, Rosemary Hollick, Milana Isaacson, Wana Kim, Alison Lydecker, Laura Miriel, Alice Sternberg, James Tonascia, Mark Van Natta, Laura Wilson, Katherine Yates

Research output: Contribution to journal › Article › peer-review

130 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

Original language	English (US)
Pages (from-to)	1904-1912
Number of pages	9
Journal	Hepatology
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/hep.22868
State	Published - Jun 2009

ASJC Scopus subject areas

Hepatology

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David, K., Kowdley, K. V., Unalp, A., Kanwal, F., Brunt, E. M., Schwimmer, J. B., Abrams, S., Arceo, D., Espinosa, D., Fairly, L., McCullough, A., Bringman, D., Dasarathy, S., Hawkins, C., Liu, Y. C., Rogers, N., Stager, M., Edwards, K., Sargent, R., ... Yates, K. (2009). Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network. Hepatology, 49(6), 1904-1912. https://doi.org/10.1002/hep.22868

David, K, Kowdley, KV, Unalp, A, Kanwal, F, Brunt, EM, Schwimmer, JB, Abrams, S, Arceo, D, Espinosa, D, Fairly, L, McCullough, A, Bringman, D, Dasarathy, S, Hawkins, C, Liu, YC, Rogers, N, Stager, M, Edwards, K, Sargent, R, Coffey, M, Murray, K, Young, M, Mohan, P, Nair, K, Diehl, AM, Gortfried, M, Guy, C, Killenberg, P, Kwan, S, Pan, YP, Piercy, D, Smith, M, Bhimalli, P, Chalasani, N, Cummings, OW, Lee, L, Ragozzino, L, Vuppalanchi, R, Scheimann, A, Torbenson, M, Klipsch, A, Molleston, J, Subbarao, G, Barlow, S, Derdoy, J, Hoffmann, J, King, D, Siegner, J, Stewart, S, Tetri, BA, Thompson, J, Behling, C, Celedon, M, Clark, L, Durelle, J, Hassanein, T, Lavine, JE, Mendoza, S, Sirlin, C, Stein, T, Tobin, A, Bambha, K, Bass, NM, Ferrell, LD, Filipowski, D, Merriman, R, Pabst, M, Rosenthal, M, Rosenthal, P, Steel, T, Boyett, S, Bryan, D, Contos, MJ, Fuchs, M, Graham, M, Jones, A, Luketic, VAC, Sandhu, B, Sanyal, AJ, Sargeant, C, Selph, K, White, M, Gyurkey, G, Mooney, J, Nelson, J, Roberts, S, Saunders, C, Stead, A, Wang, C, Yeh, M, Brunt, E, Kleiner, D, Grave, GD, Huang, TTK, Doo, E, Everhart, JE, Hoofnagle, JH, Robuck, PR, Seeff, L, Belt, P, Brancati, F, Clark, J, Colvin, R, Donithan, M, Green, M, Hollick, R, Isaacson, M, Kim, W, Lydecker, A, Miriel, L, Sternberg, A, Tonascia, J, Van Natta, M, Wilson, L & Yates, K 2009, 'Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network', Hepatology, vol. 49, no. 6, pp. 1904-1912. https://doi.org/10.1002/hep.22868

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title = "Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network",

abstract = "Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.",

author = "Kristin David and Kowdley, {Kris V.} and Aynur Unalp and Fasiha Kanwal and Brunt, {Elizabeth M.} and Schwimmer, {Jeffrey B.} and Stephanie Abrams and Diana Arceo and Denise Espinosa and Leanel Fairly and Arthur McCullough and Diane Bringman and Srinivasan Dasarathy and Carol Hawkins and Liu, {Yao Chang} and Nicholette Rogers and Margaret Stager and Kevin Edwards and Ruth Sargent and Melissa Coffey and Karen Murray and Melissa Young and Parvathi Mohan and Kavita Nair and Diehl, {Anna Mae} and Marcia Gortfried and Cynthia Guy and Paul Killenberg and Samantha Kwan and Pan, {Yi Ping} and Dawn Piercy and Melissa Smith and Prajakta Bhimalli and Naga Chalasani and Cummings, {Oscar W.} and Lydia Lee and Linda Ragozzino and Raj Vuppalanchi and Ann Scheimann and Michael Torbenson and Ann Klipsch and Jean Molleston and Girish Subbarao and Sarah Barlow and Jose Derdoy and Joyce Hoffmann and Debra King and Joan Siegner and Susan Stewart and Tetri, {Brent A.} and Judy Thompson and Cynthia Behling and Manual Celedon and Lisa Clark and Janis Durelle and Tarek Hassanein and Lavine, {Joel E.} and Susana Mendoza and Claude Sirlin and Tanya Stein and Allison Tobin and Kiran Bambha and Bass, {Nathan M.} and Ferrell, {Linda D.} and Danuta Filipowski and Raphael Merriman and Mark Pabst and Monique Rosenthal and Philip Rosenthal and Tessa Steel and Sherry Boyett and Daphne Bryan and Contos, {Melissa J.} and Michael Fuchs and Martin Graham and Amy Jones and Luketic, {Velimir A.C.} and Bimalijit Sandhu and Sanyal, {Arun J.} and Carol Sargeant and Kimberly Selph and Melanie White and Grace Gyurkey and Jody Mooney and James Nelson and Sarah Roberts and Cheryl Saunders and Alice Stead and Chia Wang and Matthew Yeh and Elizabeth Brunt and David Kleiner and Grave, {Gilman D.} and Huang, {Terry T.K.} and Edward Doo and Everhart, {James E.} and Hoofnagle, {Jay H.} and Robuck, {Patricia R.} and Leonard Seeff and Patricia Belt and Fred Brancati and Jeanne Clark and Ryan Colvin and Michele Donithan and Mika Green and Rosemary Hollick and Milana Isaacson and Wana Kim and Alison Lydecker and Laura Miriel and Alice Sternberg and James Tonascia and {Van Natta}, Mark and Laura Wilson and Katherine Yates",

year = "2009",

month = jun,

doi = "10.1002/hep.22868",

language = "English (US)",

volume = "49",

pages = "1904--1912",

journal = "Hepatology",

issn = "0270-9139",

publisher = "John Wiley and Sons Ltd",

number = "6",

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TY - JOUR

T1 - Quality of life in adults with nonalcoholic fatty liver disease

T2 - Baseline data from the nonalcoholic steatohepatitis clinical research network

AU - David, Kristin

AU - Kowdley, Kris V.

AU - Unalp, Aynur

AU - Kanwal, Fasiha

AU - Brunt, Elizabeth M.

AU - Schwimmer, Jeffrey B.

AU - Abrams, Stephanie

AU - Arceo, Diana

AU - Espinosa, Denise

AU - Fairly, Leanel

AU - McCullough, Arthur

AU - Bringman, Diane

AU - Dasarathy, Srinivasan

AU - Hawkins, Carol

AU - Liu, Yao Chang

AU - Rogers, Nicholette

AU - Stager, Margaret

AU - Edwards, Kevin

AU - Sargent, Ruth

AU - Coffey, Melissa

AU - Murray, Karen

AU - Young, Melissa

AU - Mohan, Parvathi

AU - Nair, Kavita

AU - Diehl, Anna Mae

AU - Gortfried, Marcia

AU - Guy, Cynthia

AU - Killenberg, Paul

AU - Kwan, Samantha

AU - Pan, Yi Ping

AU - Piercy, Dawn

AU - Smith, Melissa

AU - Bhimalli, Prajakta

AU - Chalasani, Naga

AU - Cummings, Oscar W.

AU - Lee, Lydia

AU - Ragozzino, Linda

AU - Vuppalanchi, Raj

AU - Scheimann, Ann

AU - Torbenson, Michael

AU - Klipsch, Ann

AU - Molleston, Jean

AU - Subbarao, Girish

AU - Barlow, Sarah

AU - Derdoy, Jose

AU - Hoffmann, Joyce

AU - King, Debra

AU - Siegner, Joan

AU - Stewart, Susan

AU - Tetri, Brent A.

AU - Thompson, Judy

AU - Behling, Cynthia

AU - Celedon, Manual

AU - Clark, Lisa

AU - Durelle, Janis

AU - Hassanein, Tarek

AU - Lavine, Joel E.

AU - Mendoza, Susana

AU - Sirlin, Claude

AU - Stein, Tanya

AU - Tobin, Allison

AU - Bambha, Kiran

AU - Bass, Nathan M.

AU - Ferrell, Linda D.

AU - Filipowski, Danuta

AU - Merriman, Raphael

AU - Pabst, Mark

AU - Rosenthal, Monique

AU - Rosenthal, Philip

AU - Steel, Tessa

AU - Boyett, Sherry

AU - Bryan, Daphne

AU - Contos, Melissa J.

AU - Fuchs, Michael

AU - Graham, Martin

AU - Jones, Amy

AU - Luketic, Velimir A.C.

AU - Sandhu, Bimalijit

AU - Sanyal, Arun J.

AU - Sargeant, Carol

AU - Selph, Kimberly

AU - White, Melanie

AU - Gyurkey, Grace

AU - Mooney, Jody

AU - Nelson, James

AU - Roberts, Sarah

AU - Saunders, Cheryl

AU - Stead, Alice

AU - Wang, Chia

AU - Yeh, Matthew

AU - Brunt, Elizabeth

AU - Kleiner, David

AU - Grave, Gilman D.

AU - Huang, Terry T.K.

AU - Doo, Edward

AU - Everhart, James E.

AU - Hoofnagle, Jay H.

AU - Robuck, Patricia R.

AU - Seeff, Leonard

AU - Belt, Patricia

AU - Brancati, Fred

AU - Clark, Jeanne

AU - Colvin, Ryan

AU - Donithan, Michele

AU - Green, Mika

AU - Hollick, Rosemary

AU - Isaacson, Milana

AU - Kim, Wana

AU - Lydecker, Alison

AU - Miriel, Laura

AU - Sternberg, Alice

AU - Tonascia, James

AU - Van Natta, Mark

AU - Wilson, Laura

AU - Yates, Katherine

PY - 2009/6

Y1 - 2009/6

N2 - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

AB - Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. The association between NAFLD and quality of life (QOL) remains unclear. These data are important to estimate the burden of illness in NAFLD. The aim was to report QOL scores of adults with NAFLD and examine the association between NAFLD severity and QOL. QOL data were collected from adults with NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network using the Short Form 36 (SF-36) survey, and scores were compared with normative U.S. population scores. Liver biopsy histology was reviewed by a central pathology committee. A total of 713 subjects with NAFLD (male = 269, female = 444) were included. Mean age of subjects was 48.3 years; 61% had definite nonalcoholic steatohepatitis (NASH), and 28% had bridging fibrosis or cirrhosis. Diabetes was present in 27% of subjects. Subjects with NAFLD had worse physical (mean, 45.2) and mental health scores (mean, 47.6) compared with the U.S. population with (mean, 50) and without (physical, 55.8; mental, 52.5) chronic illness. Subjects with NASH reported lower physical health compared with subjects with fatty liver disease without NASH (44.5 versus 47.1, P = 0.02). Subjects with cirrhosis had significantly (P<0.001) poorer physical health scores (38.4) than subjects with no (47.6), mild (46.2), moderate (44.6), or bridging fibrosis (44.6). Cirrhosis was associated with poorer physical health after adjusting for potential confounders. Mental health scores did not differ between participants with and without NASH or by degree of fibrosis. Conclusion: Adults with NAFLDhave a significant decrement inQOL.Treatment ofNAFLDshould incorporate strategies to improve QOL, especially physical health.

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UR - http://www.scopus.com/inward/citedby.url?scp=68949136754&partnerID=8YFLogxK

U2 - 10.1002/hep.22868

DO - 10.1002/hep.22868

M3 - Article

C2 - 19434741

AN - SCOPUS:68949136754

SN - 0270-9139

VL - 49

SP - 1904

EP - 1912

JO - Hepatology

JF - Hepatology

IS - 6

ER -

Quality of life in adults with nonalcoholic fatty liver disease: Baseline data from the nonalcoholic steatohepatitis clinical research network

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