Quality of life in pediatric patients affected by electrophysiologic disease

Richard J. Czosek, Amy E. Cassedy, Jo Wray, Gil Wernovsky, Jane W. Newburger, Kathleen A. Mussatto, Lynn Mahony, Ronn E. Tanel, Mitchell I. Cohen, Rodney C. Franklin, Kate L. Brown, David Rosenthal, Dennis Drotar, Bradley S. Marino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background Treatment of electrophysiologic (EP) disease in pediatric patients has improved; however, the effects on quality of life (QOL) are unknown. Objective The purpose of this study was to compare QOL within EP disease groups and to other congenital heart diseases, to evaluate the effects of cardiac rhythm devices on QOL, and to identify drivers of QOL in EP disease. Methods Cross-sectional study of patient/parent proxy-reported Pediatric Cardiac Quality of Life Inventory scores (Total, Disease Impact, Psychosocial Impact) in subjects aged 8 to 18 years from 11 centers with congenital complete heart block (CCHB), ventricular tachycardia (VT), supraventricular tachycardia (SVT), and long QT syndrome (LQTS). QOL was compared between EP disease groups and congenital heart disease groups [bicuspid aortic valve (BAV), tetralogy of Fallot (TOF), and Fontan]. General linear modeling was used to perform group comparisons and to identify predictors of QOL variation. Results Among 288 patient-parent pairs, mean age was 12.8 ± 3.0 years. CCHB (μ = 83) showed higher patient Total QOL than other EP disease cohorts (P ≤.02; LQTS μ = 73; SVT μ = 74). SVT (μ = 75) and LQTS (μ = 75) had lower patient Total scores than BAV (μ = 81; P ≤.008). Patient/parent-proxy QOL scores for all EP disease groups were not different than TOF and higher than Fontan. The presence of a cardiac rhythm device was associated with lower QOL scores in LQTS (μ = 66 vs μ = 76; P <.01). Predictors of lower patient/parent-proxy QOL included EP disease type (P ≤.03), increased medical care utilization (P ≤.04), and no parental college degree (P ≤.001). Conclusion Given the significant variation in QOL in EP disease type, stratification by EP disease type and increased medical care utilization may allow for targeted interventions to improve QOL.

Original languageEnglish (US)
Article number6093
Pages (from-to)899-908
Number of pages10
JournalHeart Rhythm
Volume12
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Quality of Life
Pediatrics
Long QT Syndrome
Supraventricular Tachycardia
Proxy
Tetralogy of Fallot
Equipment and Supplies
Heart Diseases
Ventricular Tachycardia
Cross-Sectional Studies

Keywords

  • Arrhythmia
  • Cardiac rhythm devices
  • Channelopathy
  • Electrophysiology
  • Pediatrics
  • Quality of life

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Czosek, R. J., Cassedy, A. E., Wray, J., Wernovsky, G., Newburger, J. W., Mussatto, K. A., ... Marino, B. S. (2015). Quality of life in pediatric patients affected by electrophysiologic disease. Heart Rhythm, 12(5), 899-908. [6093]. https://doi.org/10.1016/j.hrthm.2015.01.022

Quality of life in pediatric patients affected by electrophysiologic disease. / Czosek, Richard J.; Cassedy, Amy E.; Wray, Jo; Wernovsky, Gil; Newburger, Jane W.; Mussatto, Kathleen A.; Mahony, Lynn; Tanel, Ronn E.; Cohen, Mitchell I.; Franklin, Rodney C.; Brown, Kate L.; Rosenthal, David; Drotar, Dennis; Marino, Bradley S.

In: Heart Rhythm, Vol. 12, No. 5, 6093, 01.05.2015, p. 899-908.

Research output: Contribution to journalArticle

Czosek, RJ, Cassedy, AE, Wray, J, Wernovsky, G, Newburger, JW, Mussatto, KA, Mahony, L, Tanel, RE, Cohen, MI, Franklin, RC, Brown, KL, Rosenthal, D, Drotar, D & Marino, BS 2015, 'Quality of life in pediatric patients affected by electrophysiologic disease', Heart Rhythm, vol. 12, no. 5, 6093, pp. 899-908. https://doi.org/10.1016/j.hrthm.2015.01.022
Czosek RJ, Cassedy AE, Wray J, Wernovsky G, Newburger JW, Mussatto KA et al. Quality of life in pediatric patients affected by electrophysiologic disease. Heart Rhythm. 2015 May 1;12(5):899-908. 6093. https://doi.org/10.1016/j.hrthm.2015.01.022
Czosek, Richard J. ; Cassedy, Amy E. ; Wray, Jo ; Wernovsky, Gil ; Newburger, Jane W. ; Mussatto, Kathleen A. ; Mahony, Lynn ; Tanel, Ronn E. ; Cohen, Mitchell I. ; Franklin, Rodney C. ; Brown, Kate L. ; Rosenthal, David ; Drotar, Dennis ; Marino, Bradley S. / Quality of life in pediatric patients affected by electrophysiologic disease. In: Heart Rhythm. 2015 ; Vol. 12, No. 5. pp. 899-908.
@article{96b66859e98e4a779bae2bce05281bff,
title = "Quality of life in pediatric patients affected by electrophysiologic disease",
abstract = "Background Treatment of electrophysiologic (EP) disease in pediatric patients has improved; however, the effects on quality of life (QOL) are unknown. Objective The purpose of this study was to compare QOL within EP disease groups and to other congenital heart diseases, to evaluate the effects of cardiac rhythm devices on QOL, and to identify drivers of QOL in EP disease. Methods Cross-sectional study of patient/parent proxy-reported Pediatric Cardiac Quality of Life Inventory scores (Total, Disease Impact, Psychosocial Impact) in subjects aged 8 to 18 years from 11 centers with congenital complete heart block (CCHB), ventricular tachycardia (VT), supraventricular tachycardia (SVT), and long QT syndrome (LQTS). QOL was compared between EP disease groups and congenital heart disease groups [bicuspid aortic valve (BAV), tetralogy of Fallot (TOF), and Fontan]. General linear modeling was used to perform group comparisons and to identify predictors of QOL variation. Results Among 288 patient-parent pairs, mean age was 12.8 ± 3.0 years. CCHB (μ = 83) showed higher patient Total QOL than other EP disease cohorts (P ≤.02; LQTS μ = 73; SVT μ = 74). SVT (μ = 75) and LQTS (μ = 75) had lower patient Total scores than BAV (μ = 81; P ≤.008). Patient/parent-proxy QOL scores for all EP disease groups were not different than TOF and higher than Fontan. The presence of a cardiac rhythm device was associated with lower QOL scores in LQTS (μ = 66 vs μ = 76; P <.01). Predictors of lower patient/parent-proxy QOL included EP disease type (P ≤.03), increased medical care utilization (P ≤.04), and no parental college degree (P ≤.001). Conclusion Given the significant variation in QOL in EP disease type, stratification by EP disease type and increased medical care utilization may allow for targeted interventions to improve QOL.",
keywords = "Arrhythmia, Cardiac rhythm devices, Channelopathy, Electrophysiology, Pediatrics, Quality of life",
author = "Czosek, {Richard J.} and Cassedy, {Amy E.} and Jo Wray and Gil Wernovsky and Newburger, {Jane W.} and Mussatto, {Kathleen A.} and Lynn Mahony and Tanel, {Ronn E.} and Cohen, {Mitchell I.} and Franklin, {Rodney C.} and Brown, {Kate L.} and David Rosenthal and Dennis Drotar and Marino, {Bradley S.}",
year = "2015",
month = "5",
day = "1",
doi = "10.1016/j.hrthm.2015.01.022",
language = "English (US)",
volume = "12",
pages = "899--908",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Quality of life in pediatric patients affected by electrophysiologic disease

AU - Czosek, Richard J.

AU - Cassedy, Amy E.

AU - Wray, Jo

AU - Wernovsky, Gil

AU - Newburger, Jane W.

AU - Mussatto, Kathleen A.

AU - Mahony, Lynn

AU - Tanel, Ronn E.

AU - Cohen, Mitchell I.

AU - Franklin, Rodney C.

AU - Brown, Kate L.

AU - Rosenthal, David

AU - Drotar, Dennis

AU - Marino, Bradley S.

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background Treatment of electrophysiologic (EP) disease in pediatric patients has improved; however, the effects on quality of life (QOL) are unknown. Objective The purpose of this study was to compare QOL within EP disease groups and to other congenital heart diseases, to evaluate the effects of cardiac rhythm devices on QOL, and to identify drivers of QOL in EP disease. Methods Cross-sectional study of patient/parent proxy-reported Pediatric Cardiac Quality of Life Inventory scores (Total, Disease Impact, Psychosocial Impact) in subjects aged 8 to 18 years from 11 centers with congenital complete heart block (CCHB), ventricular tachycardia (VT), supraventricular tachycardia (SVT), and long QT syndrome (LQTS). QOL was compared between EP disease groups and congenital heart disease groups [bicuspid aortic valve (BAV), tetralogy of Fallot (TOF), and Fontan]. General linear modeling was used to perform group comparisons and to identify predictors of QOL variation. Results Among 288 patient-parent pairs, mean age was 12.8 ± 3.0 years. CCHB (μ = 83) showed higher patient Total QOL than other EP disease cohorts (P ≤.02; LQTS μ = 73; SVT μ = 74). SVT (μ = 75) and LQTS (μ = 75) had lower patient Total scores than BAV (μ = 81; P ≤.008). Patient/parent-proxy QOL scores for all EP disease groups were not different than TOF and higher than Fontan. The presence of a cardiac rhythm device was associated with lower QOL scores in LQTS (μ = 66 vs μ = 76; P <.01). Predictors of lower patient/parent-proxy QOL included EP disease type (P ≤.03), increased medical care utilization (P ≤.04), and no parental college degree (P ≤.001). Conclusion Given the significant variation in QOL in EP disease type, stratification by EP disease type and increased medical care utilization may allow for targeted interventions to improve QOL.

AB - Background Treatment of electrophysiologic (EP) disease in pediatric patients has improved; however, the effects on quality of life (QOL) are unknown. Objective The purpose of this study was to compare QOL within EP disease groups and to other congenital heart diseases, to evaluate the effects of cardiac rhythm devices on QOL, and to identify drivers of QOL in EP disease. Methods Cross-sectional study of patient/parent proxy-reported Pediatric Cardiac Quality of Life Inventory scores (Total, Disease Impact, Psychosocial Impact) in subjects aged 8 to 18 years from 11 centers with congenital complete heart block (CCHB), ventricular tachycardia (VT), supraventricular tachycardia (SVT), and long QT syndrome (LQTS). QOL was compared between EP disease groups and congenital heart disease groups [bicuspid aortic valve (BAV), tetralogy of Fallot (TOF), and Fontan]. General linear modeling was used to perform group comparisons and to identify predictors of QOL variation. Results Among 288 patient-parent pairs, mean age was 12.8 ± 3.0 years. CCHB (μ = 83) showed higher patient Total QOL than other EP disease cohorts (P ≤.02; LQTS μ = 73; SVT μ = 74). SVT (μ = 75) and LQTS (μ = 75) had lower patient Total scores than BAV (μ = 81; P ≤.008). Patient/parent-proxy QOL scores for all EP disease groups were not different than TOF and higher than Fontan. The presence of a cardiac rhythm device was associated with lower QOL scores in LQTS (μ = 66 vs μ = 76; P <.01). Predictors of lower patient/parent-proxy QOL included EP disease type (P ≤.03), increased medical care utilization (P ≤.04), and no parental college degree (P ≤.001). Conclusion Given the significant variation in QOL in EP disease type, stratification by EP disease type and increased medical care utilization may allow for targeted interventions to improve QOL.

KW - Arrhythmia

KW - Cardiac rhythm devices

KW - Channelopathy

KW - Electrophysiology

KW - Pediatrics

KW - Quality of life

UR - http://www.scopus.com/inward/record.url?scp=84928611311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928611311&partnerID=8YFLogxK

U2 - 10.1016/j.hrthm.2015.01.022

DO - 10.1016/j.hrthm.2015.01.022

M3 - Article

C2 - 25602174

AN - SCOPUS:84928611311

VL - 12

SP - 899

EP - 908

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 5

M1 - 6093

ER -