Quantification and visualization of oxygen partial pressure in vivo by19f NMR imaging of perfluorocarbons

M. E. Bellemann, J. Brückner, P. Peschke, G. Brix, R. P. Mason

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Due to the high solubility ofmolecular oxygen in perfluorocarbons (PFC), this class offluorinated compounds hos gained wide-spread interestfor its biomedical application äs temporary blood substitutes and as radiosensitizers. Since the observation that the NMR spin-lattice relaxation times (T1) of some 19F PFC resonances are sensitive to oxygen tension (pOJ, this paramagnetic effect hos been used to non-invasively probe pO2 in vivo. In this study, combined 19F/HNMR Image data ofCopenhagen rats öfter PFC application were evaluated with the Software package MATLAB. The analysis of the 19F NMR data resulted in Image matrices with calculated Tt values in each pixel By using a calibration curve, the corresponding pO2values were computed. Color overlays of pO2contour lines on Trweighted 1H Images show a good anatomical-foinctional correspondence.

Original languageEnglish (US)
Pages (from-to)451-454
Number of pages4
JournalBiomedizinische Technik
Volume47
Issue numbers1a
DOIs
StatePublished - Jan 1 2002

Keywords

  • Nuclear magnetic resonance (NMR)
  • Oxygen partial pressure (pO)
  • Tissue oxygenation

ASJC Scopus subject areas

  • Biomedical Engineering

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