Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy

Tian Fenghua, Mauricio R. Delgado, Sameer C. Dhamne, Bilal Khan, George Alexandrakis, Mario I. Romero, Linsley Smith, Dahlia Reid, Nancy J. Clegg, Hanli Liu

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Cerebral palsy (CP) is the most common motor disorder in children. Currently available neuroimaging techniques require complete body confinement and steadiness and thus are extremely difficult for pediatric patients. Here, we report the use and quantification of functional near infrared spectroscopy (fNIRS) to investigate the functional reorganization of the sensorimotor cortex in children with hemiparetic CP. Ten of sixteen children with congenital hemiparesis were measured during finger tapping tasks and compared with eight of sixteen age-matched healthy children, with an overall measurement success rate of 60%. Spatiotemporal analysis was introduced to quantify the motor activation and brain laterality. Such a quantitative approach reveals a consistent, contralateral motor activation in healthy children at 7 years of age or older. In sharp contrast, children with congenital hemiparesis exhibit all three of contralateral, bilateral and ipsilateral motor activations, depending on specific ages of the pediatric subjects. This study clearly demonstrates the feasibility of fNIRS to be utilized for investigating cortical reorganization in children with CP or other cortical disorders.

Original languageEnglish (US)
Pages (from-to)25973-25986
Number of pages14
JournalOptics Express
Volume18
Issue number25
DOIs
StatePublished - Dec 6 2010

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infrared spectroscopy
activation
lateral stability
disorders
cortexes
brain

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy. / Fenghua, Tian; Delgado, Mauricio R.; Dhamne, Sameer C.; Khan, Bilal; Alexandrakis, George; Romero, Mario I.; Smith, Linsley; Reid, Dahlia; Clegg, Nancy J.; Liu, Hanli.

In: Optics Express, Vol. 18, No. 25, 06.12.2010, p. 25973-25986.

Research output: Contribution to journalArticle

Fenghua, T, Delgado, MR, Dhamne, SC, Khan, B, Alexandrakis, G, Romero, MI, Smith, L, Reid, D, Clegg, NJ & Liu, H 2010, 'Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy', Optics Express, vol. 18, no. 25, pp. 25973-25986. https://doi.org/10.1364/OE.18.025973
Fenghua, Tian ; Delgado, Mauricio R. ; Dhamne, Sameer C. ; Khan, Bilal ; Alexandrakis, George ; Romero, Mario I. ; Smith, Linsley ; Reid, Dahlia ; Clegg, Nancy J. ; Liu, Hanli. / Quantification of functional near infrared spectroscopy to assess cortical reorganization in children with cerebral palsy. In: Optics Express. 2010 ; Vol. 18, No. 25. pp. 25973-25986.
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