Quantification strategies for MRI

Olivier M. Girard, Ludovic De Rochefort, Marie Poirier-Quinot, Luc Darrasse, Robert F. Mattrey

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Quantification strategies have been a long-standing challenge since the early days of magnetic resonance molecular and cellular imaging. Quantitative imaging is desirable in the framework of comparative or follow-up studies in order to establish objective evidences of a specific target expression pertaining to a specific disease. Numerous strategies of increasing complexity have been proposed to address this need. In this chapter, common strategies related to quantitative molecular imaging for MRI are briefly reviewed and their respective outcomes are discussed. The focus is on relaxation contrast agents (CAs) that generate magnetic resonance contrast by affecting the proton relaxation times, and which are the most common kind of CAs used in MRI. Particular attention is paid to cutting-edge applications that enable local CA quantification as well as distinction of the bound/activated subpopulation of the CA.

Original languageEnglish (US)
Title of host publicationMolecular Imaging Techniques
Subtitle of host publicationNew Frontiers
PublisherFuture Medicine Ltd.
Pages67-80
Number of pages14
ISBN (Electronic)9781909453401
ISBN (Print)9781909453418
DOIs
StatePublished - Oct 1 2013

Fingerprint

Contrast Media
Molecular Imaging
Magnetic Resonance Spectroscopy
Protons

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Girard, O. M., De Rochefort, L., Poirier-Quinot, M., Darrasse, L., & Mattrey, R. F. (2013). Quantification strategies for MRI. In Molecular Imaging Techniques: New Frontiers (pp. 67-80). Future Medicine Ltd.. https://doi.org/10.4155/EBO.13.146

Quantification strategies for MRI. / Girard, Olivier M.; De Rochefort, Ludovic; Poirier-Quinot, Marie; Darrasse, Luc; Mattrey, Robert F.

Molecular Imaging Techniques: New Frontiers. Future Medicine Ltd., 2013. p. 67-80.

Research output: Chapter in Book/Report/Conference proceedingChapter

Girard, OM, De Rochefort, L, Poirier-Quinot, M, Darrasse, L & Mattrey, RF 2013, Quantification strategies for MRI. in Molecular Imaging Techniques: New Frontiers. Future Medicine Ltd., pp. 67-80. https://doi.org/10.4155/EBO.13.146
Girard OM, De Rochefort L, Poirier-Quinot M, Darrasse L, Mattrey RF. Quantification strategies for MRI. In Molecular Imaging Techniques: New Frontiers. Future Medicine Ltd. 2013. p. 67-80 https://doi.org/10.4155/EBO.13.146
Girard, Olivier M. ; De Rochefort, Ludovic ; Poirier-Quinot, Marie ; Darrasse, Luc ; Mattrey, Robert F. / Quantification strategies for MRI. Molecular Imaging Techniques: New Frontiers. Future Medicine Ltd., 2013. pp. 67-80
@inbook{d4f1bc53507445fe90665db1cf29b480,
title = "Quantification strategies for MRI",
abstract = "Quantification strategies have been a long-standing challenge since the early days of magnetic resonance molecular and cellular imaging. Quantitative imaging is desirable in the framework of comparative or follow-up studies in order to establish objective evidences of a specific target expression pertaining to a specific disease. Numerous strategies of increasing complexity have been proposed to address this need. In this chapter, common strategies related to quantitative molecular imaging for MRI are briefly reviewed and their respective outcomes are discussed. The focus is on relaxation contrast agents (CAs) that generate magnetic resonance contrast by affecting the proton relaxation times, and which are the most common kind of CAs used in MRI. Particular attention is paid to cutting-edge applications that enable local CA quantification as well as distinction of the bound/activated subpopulation of the CA.",
author = "Girard, {Olivier M.} and {De Rochefort}, Ludovic and Marie Poirier-Quinot and Luc Darrasse and Mattrey, {Robert F.}",
year = "2013",
month = "10",
day = "1",
doi = "10.4155/EBO.13.146",
language = "English (US)",
isbn = "9781909453418",
pages = "67--80",
booktitle = "Molecular Imaging Techniques",
publisher = "Future Medicine Ltd.",

}

TY - CHAP

T1 - Quantification strategies for MRI

AU - Girard, Olivier M.

AU - De Rochefort, Ludovic

AU - Poirier-Quinot, Marie

AU - Darrasse, Luc

AU - Mattrey, Robert F.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Quantification strategies have been a long-standing challenge since the early days of magnetic resonance molecular and cellular imaging. Quantitative imaging is desirable in the framework of comparative or follow-up studies in order to establish objective evidences of a specific target expression pertaining to a specific disease. Numerous strategies of increasing complexity have been proposed to address this need. In this chapter, common strategies related to quantitative molecular imaging for MRI are briefly reviewed and their respective outcomes are discussed. The focus is on relaxation contrast agents (CAs) that generate magnetic resonance contrast by affecting the proton relaxation times, and which are the most common kind of CAs used in MRI. Particular attention is paid to cutting-edge applications that enable local CA quantification as well as distinction of the bound/activated subpopulation of the CA.

AB - Quantification strategies have been a long-standing challenge since the early days of magnetic resonance molecular and cellular imaging. Quantitative imaging is desirable in the framework of comparative or follow-up studies in order to establish objective evidences of a specific target expression pertaining to a specific disease. Numerous strategies of increasing complexity have been proposed to address this need. In this chapter, common strategies related to quantitative molecular imaging for MRI are briefly reviewed and their respective outcomes are discussed. The focus is on relaxation contrast agents (CAs) that generate magnetic resonance contrast by affecting the proton relaxation times, and which are the most common kind of CAs used in MRI. Particular attention is paid to cutting-edge applications that enable local CA quantification as well as distinction of the bound/activated subpopulation of the CA.

UR - http://www.scopus.com/inward/record.url?scp=84937716721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937716721&partnerID=8YFLogxK

U2 - 10.4155/EBO.13.146

DO - 10.4155/EBO.13.146

M3 - Chapter

AN - SCOPUS:84937716721

SN - 9781909453418

SP - 67

EP - 80

BT - Molecular Imaging Techniques

PB - Future Medicine Ltd.

ER -