Quantifying Heterogeneity in Emphysema from High-Resolution Computed Tomography. A Lung Tissue Research Consortium Study.

Cuneyt Yilmaz, Dan M. Dane, Nova C. Patel, Connie C W Hsia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Rationale and Objectives: To quantify spatial distribution of emphysema using high-resolution computed tomography (HRCT), we applied semiautomated analysis with internal attenuation calibration to measure regional air volume, tissue volume, and fractional tissue volume (FTV = tissue/[air + tissue] volume) in well-characterized patients studied by the Lung Tissue Research Consortium (LTRC). Methods: HRCT was obtained at supine end-inspiration and end-expiration, and prone end-inspiration from 31 patients with mild, moderate, severe, or very severe emphysema (stages II-V, forced expiratory volume at 1 second >75%, 51%-75%, 21%-50% and ≤20% predicted, respectively). Control data were from 20 healthy non-smokers (stage I). Each lobe was analyzed separately. Heterogeneity of FTV was assessed from coefficients of variation (CV) within and among lobes, and the kurtosis and skewness of FTV histograms. Results: In emphysema, lobar air volume increased up to 177% above normal except in the right middle lobe. Lobar tissue volume increased up to 107% in mild-moderate stages then normalized in advanced stages. Normally, FTV was up to 82% higher in lower than upper lobes. In mild-moderate emphysema, lobar FTV increased by up to 74% above normal at supine inspiration. In severe emphysema, FTV declined below normal in all lobes and positions in correlation with pulmonary function ( P < .05). Markers of FTV heterogeneity increased steadily with disease stage in correlation with pulmonary function ( P < .05); the pattern is distinct from that seen in interstitial lung disease (ILD). Conclusion: CT-derived biomarkers differentiate the spatial patterns of emphysema distribution and heterogeneity from that in ILD. Early emphysema is associated with elevated tissue volume and FTV, consistent with hyperemia, inflammation or atelectasis.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalAcademic Radiology
Volume20
Issue number2
DOIs
StatePublished - Feb 2013

Fingerprint

Emphysema
Tomography
Lung
Research
Air
Interstitial Lung Diseases
Pulmonary Atelectasis
Hyperemia
Forced Expiratory Volume
Calibration
Biomarkers
Inflammation

Keywords

  • Coefficient of variation
  • CT scan
  • Fractional tissue volume
  • Image analysis
  • Kurtosis
  • Skewness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantifying Heterogeneity in Emphysema from High-Resolution Computed Tomography. A Lung Tissue Research Consortium Study. / Yilmaz, Cuneyt; Dane, Dan M.; Patel, Nova C.; Hsia, Connie C W.

In: Academic Radiology, Vol. 20, No. 2, 02.2013, p. 181-193.

Research output: Contribution to journalArticle

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title = "Quantifying Heterogeneity in Emphysema from High-Resolution Computed Tomography. A Lung Tissue Research Consortium Study.",
abstract = "Rationale and Objectives: To quantify spatial distribution of emphysema using high-resolution computed tomography (HRCT), we applied semiautomated analysis with internal attenuation calibration to measure regional air volume, tissue volume, and fractional tissue volume (FTV = tissue/[air + tissue] volume) in well-characterized patients studied by the Lung Tissue Research Consortium (LTRC). Methods: HRCT was obtained at supine end-inspiration and end-expiration, and prone end-inspiration from 31 patients with mild, moderate, severe, or very severe emphysema (stages II-V, forced expiratory volume at 1 second >75{\%}, 51{\%}-75{\%}, 21{\%}-50{\%} and ≤20{\%} predicted, respectively). Control data were from 20 healthy non-smokers (stage I). Each lobe was analyzed separately. Heterogeneity of FTV was assessed from coefficients of variation (CV) within and among lobes, and the kurtosis and skewness of FTV histograms. Results: In emphysema, lobar air volume increased up to 177{\%} above normal except in the right middle lobe. Lobar tissue volume increased up to 107{\%} in mild-moderate stages then normalized in advanced stages. Normally, FTV was up to 82{\%} higher in lower than upper lobes. In mild-moderate emphysema, lobar FTV increased by up to 74{\%} above normal at supine inspiration. In severe emphysema, FTV declined below normal in all lobes and positions in correlation with pulmonary function ( P < .05). Markers of FTV heterogeneity increased steadily with disease stage in correlation with pulmonary function ( P < .05); the pattern is distinct from that seen in interstitial lung disease (ILD). Conclusion: CT-derived biomarkers differentiate the spatial patterns of emphysema distribution and heterogeneity from that in ILD. Early emphysema is associated with elevated tissue volume and FTV, consistent with hyperemia, inflammation or atelectasis.",
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