Quantifying tracer levels of 2H2O enrichment from microliter amounts of plasma and urine by 2H NMR

John G. Jones, Matthew Merritt, Craig Malloy

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

A simple and sensitive 2H NMR measurement of 2H2O enrichment from a 10 μl volume of body fluid is presented. The method allows 2H-enrichment levels of 0.1% or above to be rapidly determined from 10 μl of plasma or urine. The measurement is insensitive to the presence of plasma protein, allowing direct analysis of 2H2O enrichment from native plasma samples.

Original languageEnglish (US)
Pages (from-to)156-158
Number of pages3
JournalMagnetic resonance in medicine
Volume45
Issue number1
DOIs
StatePublished - Jan 20 2001

Keywords

  • Biosynthetic pathways
  • Body water
  • Deuterium
  • Gluconeogenesis
  • Tracer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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