Abstract
Hemispheric swelling and area of infarction, two parameters of cerebral focal ischemic damage, were identified and quantified from T2-weighted magnetic resonance imaging (MRI) two days after occlusion of the middle cerebral artery (MCAO) in spontaneously hypertensive rat (SHR) brains. Results were compared with these measures quantified from 2.3,5-triphenyltetrazolium hydrochloride (TTC)- and hematoxylin and eosin (H&E)-stained histologic sections in the same brains. The degree of hemispheric swelling and infarct size determined by MRI were highly correlated to the measurements as determined in the TTC- and H&E-stained tissues. These results demonstrate that the focal ischemic damaged area and associated tissue swelling identified by MRI is quantitatively similar to, and thus, is representative of actual tissue damage/changes that can be identified by gross or histologic examination.
Original language | English (US) |
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Pages (from-to) | 285-291 |
Number of pages | 7 |
Journal | Brain Research Bulletin |
Volume | 26 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1991 |
Keywords
- Hemispheric swelling
- Histology
- Infarct size
- Ischemic tissue damage
- Magnetic resonance imaging (MRI)
ASJC Scopus subject areas
- General Neuroscience