Quantitative EEG amplitude across REM sleep periods in depression

Preliminary report

Marcus P. Liscombe, Robert F. Hoffmann, Madhukar H. Trivedi, Marc K. Parker, A. John Rush, Roseanne Armitage

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). Methods: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. Results: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. Conclusions: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.

Original languageEnglish (US)
Pages (from-to)40-46
Number of pages7
JournalJournal of Psychiatry and Neuroscience
Volume27
Issue number1
StatePublished - 2002

Fingerprint

REM Sleep
Electroencephalography
Sleep
Depression
Major Depressive Disorder
Eye Movements
Outpatients

Keywords

  • Alpha rhythm
  • Beta rhythm
  • Delta rhythm
  • Depressive disorder
  • Electroencephalography
  • Sex factors
  • Sleep stages
  • Sleep, REM
  • Theta rhythm

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Liscombe, M. P., Hoffmann, R. F., Trivedi, M. H., Parker, M. K., Rush, A. J., & Armitage, R. (2002). Quantitative EEG amplitude across REM sleep periods in depression: Preliminary report. Journal of Psychiatry and Neuroscience, 27(1), 40-46.

Quantitative EEG amplitude across REM sleep periods in depression : Preliminary report. / Liscombe, Marcus P.; Hoffmann, Robert F.; Trivedi, Madhukar H.; Parker, Marc K.; Rush, A. John; Armitage, Roseanne.

In: Journal of Psychiatry and Neuroscience, Vol. 27, No. 1, 2002, p. 40-46.

Research output: Contribution to journalArticle

Liscombe, MP, Hoffmann, RF, Trivedi, MH, Parker, MK, Rush, AJ & Armitage, R 2002, 'Quantitative EEG amplitude across REM sleep periods in depression: Preliminary report', Journal of Psychiatry and Neuroscience, vol. 27, no. 1, pp. 40-46.
Liscombe, Marcus P. ; Hoffmann, Robert F. ; Trivedi, Madhukar H. ; Parker, Marc K. ; Rush, A. John ; Armitage, Roseanne. / Quantitative EEG amplitude across REM sleep periods in depression : Preliminary report. In: Journal of Psychiatry and Neuroscience. 2002 ; Vol. 27, No. 1. pp. 40-46.
@article{e6d5db6cc2d8436abbb4852cf9f21984,
title = "Quantitative EEG amplitude across REM sleep periods in depression: Preliminary report",
abstract = "Objective: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). Methods: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. Results: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. Conclusions: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.",
keywords = "Alpha rhythm, Beta rhythm, Delta rhythm, Depressive disorder, Electroencephalography, Sex factors, Sleep stages, Sleep, REM, Theta rhythm",
author = "Liscombe, {Marcus P.} and Hoffmann, {Robert F.} and Trivedi, {Madhukar H.} and Parker, {Marc K.} and Rush, {A. John} and Roseanne Armitage",
year = "2002",
language = "English (US)",
volume = "27",
pages = "40--46",
journal = "Journal of Psychiatry and Neuroscience",
issn = "1180-4882",
publisher = "Canadian Medical Association",
number = "1",

}

TY - JOUR

T1 - Quantitative EEG amplitude across REM sleep periods in depression

T2 - Preliminary report

AU - Liscombe, Marcus P.

AU - Hoffmann, Robert F.

AU - Trivedi, Madhukar H.

AU - Parker, Marc K.

AU - Rush, A. John

AU - Armitage, Roseanne

PY - 2002

Y1 - 2002

N2 - Objective: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). Methods: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. Results: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. Conclusions: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.

AB - Objective: To determine if there are significant differences in the temporal organization of rapid eye movement (REM) sleep microarchitecture between healthy controls and outpatients with major depressive disorder (MDD). Methods: Forty age-matched subjects, 20 men and 20 women, half with MDD, were selected from an archive of sleep electroencephalography (EEG) data collected under identical conditions. Each participant spent 2 consecutive nights in the Sleep Study Unit of the University of Texas Southwestern Medical Center at Dallas, the first of which served as adaptation. The average amplitude in each of 5 conventional EEG frequency bands was computed for each REM period across the second night. Data were then coded for group and sex. Results: Aside from REM latency, none of the key sleep macroarchitectural variables differentiated MDD patients from controls. REM latency was longest in men with MDD. Sleep microarchitecture, however, did show a number of between-group differences. In general, slower frequencies declined across REM periods, with a significant REM period effect for delta, theta and alpha amplitude. Group x sex interactions were also obtained for theta and alpha. Beta activity showed a unique temporal profile in each group, supported by a significant REM period x group x sex interaction. In addition, the temporal change in theta amplitude across REM periods was most striking in women with MDD. Conclusions: This study suggests that, like during non-REM sleep, EEG amplitude shows a systematic temporal change over successive REM sleep periods and also shows elements that are both disease- and sex-dependent.

KW - Alpha rhythm

KW - Beta rhythm

KW - Delta rhythm

KW - Depressive disorder

KW - Electroencephalography

KW - Sex factors

KW - Sleep stages

KW - Sleep, REM

KW - Theta rhythm

UR - http://www.scopus.com/inward/record.url?scp=0036251803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036251803&partnerID=8YFLogxK

M3 - Article

VL - 27

SP - 40

EP - 46

JO - Journal of Psychiatry and Neuroscience

JF - Journal of Psychiatry and Neuroscience

SN - 1180-4882

IS - 1

ER -