Quantitative Iodine-124 imaging on animal PET

Rutao Yao, Swaminathan Balakrishnan, Sonal Ambwani, Vinay Rathod, Yiping Shao

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

With a half-live of 4.2 days, Iodine-124 (124I) is suitable for studying antibodies and drug analogues in animals that have a biological half-live in days. The special challenges with 124I imaging on animal PET are: 1) the high fraction of high-energy, non-annihilation gamma-rays that introduce true coincidences which elevate the image background activity, and 2) the significant degradation of spatial resolution due to the high positron energies. By simulations and experiments on an animal PET scanner, we characterized these two unique degradation factors and evaluated the corresponding correction methods. The preliminary results of applying non-annihilation true coincidence correction and using 124I specific point spread function in the system matrix of reconstruction algorithm showed improved contrast and resolution recovery. These findings indicate that higher-resolution, quantitative 124I applications can be achieved.

Original languageEnglish (US)
Title of host publication2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference
Pages1649-1652
Number of pages4
DOIs
StatePublished - Dec 1 2005
EventNuclear Science Symposium Conference Record, 2005 IEEE - , Puerto Rico
Duration: Oct 23 2005Oct 29 2005

Publication series

NameIEEE Nuclear Science Symposium Conference Record
Volume3
ISSN (Print)1095-7863

Other

OtherNuclear Science Symposium Conference Record, 2005 IEEE
CountryPuerto Rico
Period10/23/0510/29/05

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Yao, R., Balakrishnan, S., Ambwani, S., Rathod, V., & Shao, Y. (2005). Quantitative Iodine-124 imaging on animal PET. In 2005 IEEE Nuclear Science Symposium Conference Record -Nuclear Science Symposium and Medical Imaging Conference (pp. 1649-1652). [1596636] (IEEE Nuclear Science Symposium Conference Record; Vol. 3). https://doi.org/10.1109/NSSMIC.2005.1596636