Quantitative metabolic flux analysis reveals an unconventional pathway of fatty acid synthesis in cancer cells deficient for the mitochondrial citrate transport protein

Engineering & Materials Science

• Carrier Proteins 97%
• Fatty acids 74%
• Cells 59%
• Fluxes 49%
• Oxidoreductases 36%
• Glucose 34%
• Carboxylation 24%
• Metabolism 15%
• Lipogenesis 13%
• Enantiomers 10%
• Mitochondria 9%
• Biosynthesis 9%
• Carbon 9%
• Lipids 8%
• Oxidation-Reduction 7%
• Tracers 7%
• Pathology 6%
• Acids 5%

Medicine & Life Sciences

• Metabolic Flux Analysis 100%
• Citric Acid 66%
• Fatty Acids 51%
• Carrier Proteins 51%
• Protein Deficiency 24%
• Neoplasms 19%
• Isocitrate Dehydrogenase 19%
• alpha-hydroxyglutarate 15%
• Cytosol 13%
• Glucose 11%
• Glutamine 9%
• Carbon 9%
• Glucose 1-Dehydrogenase 7%
• Pyruvate Carboxylase 7%
• Acetyl Coenzyme A 6%
• Ketoglutaric Acids 6%
• Lipogenesis 5%
• Pyruvic Acid 5%
• Oxidation-Reduction 4%
• Lactic Acid 4%
• Cultured Cells 3%
• Mitochondria 3%
• Homeostasis 3%
• Lipids 3%
• Pathology 2%
• Phenotype 2%

Chemical Compounds

• Metabolic 49%
• Fatty Acid 49%
• Lipogenic 26%
• Protein 25%
• Carboxylation 18%
• Pyruvate 15%
• 2-Hydroxyglutarate 14%
• Pharmacological Metabolism 11%
• Glucose 11%
• Acetyl-CoA 9%
• Glutamine 8%
• Lactate 7%
• Carbon Atom 7%
• Biosynthesis 6%
• Enantiomer 5%
• Lipid 5%
• Acid 2%