Quantitative morphology of compensatory lung growth

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Compensatory lung growth is defined by the absolute increases in the quantity of functioning lung tissue in response to injury and/or disease, leading to a positive impact on functional outcome. The pneumonectomy model is used as an example to illustrate the salient features of compensatory growth and the specific considerations in its morphological quantification, including techniques of sampling and analysis, resolution of ultrastructural details, selection of markers for measurement, and interpretation of results in the context of organ architecture and physiology. The potential for structure-function dissociation is described in the present article. The current paper will discuss the application of high-resolution computed tomography to noninvasively quantify regional anatomy as well as temporal evolution of lung growth. Copyright

Original languageEnglish (US)
Pages (from-to)148-156
Number of pages9
JournalEuropean Respiratory Review
Volume15
Issue number101
DOIs
StatePublished - Dec 1 2006

Keywords

  • Airway
  • Diffusing capacity
  • High-resolution computed tomography
  • Lung alveoli
  • Morphometry
  • Pneumonectomy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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