Quantitative sonoelastography for the in vivo assessment of skeletal muscle viscoelasticity

Kenneth Hoyt, Timothy Kneezel, Benjamin Castaneda, Kevin J. Parker

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

A novel quantitative sonoelastography technique for assessing the viscoelastic properties of skeletal muscle tissue was developed. Slowly propagating shear wave interference patterns (termed crawling waves) were generated using a two-source configuration vibrating normal to the surface. Theoretical models predict crawling wave displacement fields, which were validated through phantom studies. In experiments, a viscoelastic model was fit to dispersive shear wave speed sonoelastographic data using nonlinear least-squares techniques to determine frequency-independent shear modulus and viscosity estimates. Shear modulus estimates derived using the viscoelastic model were in agreement with that obtained by mechanical testing on phantom samples. Preliminary sonoelastographic data acquired in healthy human skeletal muscles confirm that high-quality quantitative elasticity data can be acquired in vivo. Studies on relaxed muscle indicate discernible differences in both shear modulus and viscosity estimates between different skeletal muscle groups. Investigations into the dynamic viscoelastic properties of (healthy) human skeletal muscles revealed that voluntarily contracted muscles exhibit considerable increases in both shear modulus and viscosity estimates as compared to the relaxed state. Overall, preliminary results are encouraging and quantitative sonoelastography may prove clinically feasible for in vivo characterization of the dynamic viscoelastic properties of human skeletal muscle.

Original languageEnglish (US)
Pages (from-to)4063-4080
Number of pages18
JournalPhysics in Medicine and Biology
Volume53
Issue number15
DOIs
StatePublished - Aug 7 2008

Fingerprint

Elasticity Imaging Techniques
skeletal muscle
viscoelasticity
Viscoelasticity
Muscle
Skeletal Muscle
Viscosity
shear
Shear viscosity
Elastic moduli
viscosity
estimates
muscles
Muscles
S waves
Shear waves
Elasticity
Least-Squares Analysis
Wave interference
Mechanical testing

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Quantitative sonoelastography for the in vivo assessment of skeletal muscle viscoelasticity. / Hoyt, Kenneth; Kneezel, Timothy; Castaneda, Benjamin; Parker, Kevin J.

In: Physics in Medicine and Biology, Vol. 53, No. 15, 07.08.2008, p. 4063-4080.

Research output: Contribution to journalArticle

Hoyt, Kenneth ; Kneezel, Timothy ; Castaneda, Benjamin ; Parker, Kevin J. / Quantitative sonoelastography for the in vivo assessment of skeletal muscle viscoelasticity. In: Physics in Medicine and Biology. 2008 ; Vol. 53, No. 15. pp. 4063-4080.
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