Quantitative 1H and hyperpolarized 3He magnetic resonance imaging: Comparison in chronic obstructive pulmonary disease and healthy never-smokers

Amir M. Owrangi, Jian X. Wang, Andrew Wheatley, David G. McCormack, Grace Parraga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalEuropean Journal of Radiology
Volume83
Issue number1
DOIs
StatePublished - Jan 1 2014

Fingerprint

Chronic Obstructive Pulmonary Disease
Tomography
Magnetic Resonance Imaging
Emphysema
Noble Gases
Lung
Pulmonary Emphysema
Diffusion Magnetic Resonance Imaging
Plethysmography
Densitometry
Spirometry

Keywords

  • H MR signal intensity
  • Apparent diffusion coefficient
  • Emphysema
  • Hyperpolarized He
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Quantitative 1H and hyperpolarized 3He magnetic resonance imaging : Comparison in chronic obstructive pulmonary disease and healthy never-smokers. / Owrangi, Amir M.; Wang, Jian X.; Wheatley, Andrew; McCormack, David G.; Parraga, Grace.

In: European Journal of Radiology, Vol. 83, No. 1, 01.01.2014, p. 64-72.

Research output: Contribution to journalArticle

@article{d39a0d9f41454f57bb6b4fa5258f11cc,
title = "Quantitative 1H and hyperpolarized 3He magnetic resonance imaging: Comparison in chronic obstructive pulmonary disease and healthy never-smokers",
abstract = "Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.",
keywords = "H MR signal intensity, Apparent diffusion coefficient, Emphysema, Hyperpolarized He, Magnetic resonance imaging",
author = "Owrangi, {Amir M.} and Wang, {Jian X.} and Andrew Wheatley and McCormack, {David G.} and Grace Parraga",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.ejrad.2012.02.018",
language = "English (US)",
volume = "83",
pages = "64--72",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Quantitative 1H and hyperpolarized 3He magnetic resonance imaging

T2 - Comparison in chronic obstructive pulmonary disease and healthy never-smokers

AU - Owrangi, Amir M.

AU - Wang, Jian X.

AU - Wheatley, Andrew

AU - McCormack, David G.

AU - Parraga, Grace

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.

AB - Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.

KW - H MR signal intensity

KW - Apparent diffusion coefficient

KW - Emphysema

KW - Hyperpolarized He

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=84892372266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84892372266&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2012.02.018

DO - 10.1016/j.ejrad.2012.02.018

M3 - Article

C2 - 22571928

AN - SCOPUS:84892372266

VL - 83

SP - 64

EP - 72

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 1

ER -