TY - JOUR
T1 - Quantitative 1H and hyperpolarized 3He magnetic resonance imaging
T2 - Comparison in chronic obstructive pulmonary disease and healthy never-smokers
AU - Owrangi, Amir M.
AU - Wang, Jian X.
AU - Wheatley, Andrew
AU - McCormack, David G.
AU - Parraga, Grace
N1 - Funding Information:
A. Owrangi gratefully acknowledges support from the Western Graduate Research Fund provided by The University of Western Ontario (London, Canada). Dr Parraga acknowledges salary support from the Canadian Institutes of Health Research New Investigator Award. We also thank S. Halko, S. McKay for clinical coordination and T. Szekeres for MRI of research subjects. We acknowledge funding support from the Canadian Institutes of Health Research Operating Grants and Team Grant ( MOP #97748 , MOP #106437 , FRN #97687 ). The use of an onsite hyperpolarized 3 He gas polarizer system [HeliSpin™, General Electric Health Care (GEHC), Durham, NC] was provided to Robarts Research Institute through an agreement with GEHC for which we pay He gas polarizer system [HeliSpin™, General Electric Health Care (GEHC), Durham, NC] was provided to Robarts Research Institute through an agreement with GEHC for which we pay $100,000/year.00,000/year.
PY - 2014/1
Y1 - 2014/1
N2 - Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.
AB - Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.
KW - Apparent diffusion coefficient
KW - Emphysema
KW - H MR signal intensity
KW - Hyperpolarized He
KW - Magnetic resonance imaging
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U2 - 10.1016/j.ejrad.2012.02.018
DO - 10.1016/j.ejrad.2012.02.018
M3 - Article
C2 - 22571928
AN - SCOPUS:84892372266
SN - 0720-048X
VL - 83
SP - 64
EP - 72
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 1
ER -