Quantitative 1H and hyperpolarized 3He magnetic resonance imaging: Comparison in chronic obstructive pulmonary disease and healthy never-smokers

Amir M. Owrangi, Jian X. Wang, Andrew Wheatley, David G. McCormack, Grace Parraga

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: The aim of this study was to quantitatively evaluate the relationship between short echo time pulmonary 1H magnetic resonance imaging (MRI) signal intensity (SI) and 3He MRI apparent diffusion coefficients (ADC), high-resolution computed tomography (CT) measurements of emphysema, and pulmonary function measurements. Materials and methods: Nine healthy never-smokers and 11 COPD subjects underwent same-day plethysmography, spirometry, short echo time ((TE) = 1.2 ms) 1H and diffusion-weighted hyperpolarized 3He MRI (b = 1.6 s/cm2) at 3.0 T. In addition, for COPD subjects only, CT densitometry was also performed. Results: Mean 1H SI was significantly greater for never-smokers (12.1 ± 1.1 arbitrary units (AU)) compared to COPD subjects (10.9 ± 1.3 AU, p = 0.04). The 1H SI AP-gradient was also significantly greater for never-smokers (0.40 AU/cm, R2 = 0.94) compared to COPD subjects (0.29 AU/cm, R2 = 0.968, p = 0.05). There was a significant correlation between 1H SI and 3He ADC (r = -0.58, p = 0.008) and significant correlations between 1H MR SI and CT measurements of emphysema (RA950, r = -0.69, p = 0.02 and HU15, r = 0.66, p = 0.03). Conclusions: The significant and moderately strong relationship between 1H SI and 3He ADC, as well as between 1H SI and CT measurements of emphysema suggests that these imaging methods and measurements may be quantifying similar tissue changes in COPD and that pulmonary 1H SI may be used to monitor emphysema as a complement to CT and noble gas MRI.

Original languageEnglish (US)
Pages (from-to)64-72
Number of pages9
JournalEuropean Journal of Radiology
Volume83
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Apparent diffusion coefficient
  • Emphysema
  • H MR signal intensity
  • Hyperpolarized He
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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