Quantitative variation in la antigen expression plays a central role in immune regulation

Charles A. Janeway, Kim Bottomly, John Babich, Patricia Conrad, Suzanne Conzen, Barry Jones, Jonathan Kaye, Michael Katz, Laila McVay, Donal B. Murphy, John Tite

Research output: Contribution to journalReview article

243 Scopus citations

Abstract

The analysis of la antigen function has focused primarily on allelic variants of Ia molecules. In this review Charles Janeway and his colleagues discuss evidence that quantitative rather than qualitative variation in Ia antigen expression had a major role in immunoregulation and immunologically mediated disease.

Original languageEnglish (US)
Pages (from-to)99-105
Number of pages7
JournalImmunology Today
Volume5
Issue number4
DOIs
StatePublished - Apr 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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    Janeway, C. A., Bottomly, K., Babich, J., Conrad, P., Conzen, S., Jones, B., Kaye, J., Katz, M., McVay, L., Murphy, D. B., & Tite, J. (1984). Quantitative variation in la antigen expression plays a central role in immune regulation. Immunology Today, 5(4), 99-105. https://doi.org/10.1016/0167-5699(84)90043-4