@article{cc14d32301694568a03fdfec28b4bf7f,
title = "Quinpramine is a novel compound effective in ameliorating brain autoimmune disease",
abstract = "Acridine-iminodibenzyl chimeric compounds were previously introduced as a class of cholesterol-redistributing substances with antiprion effects. Here, we show that administration of the lead compound quinpramine to mice with experimental autoimmune encephalitis, an animal model of multiple sclerosis (MS), significantly ameliorates disease in preventive and therapeutic paradigms. Quinpramine treatment decreased the number of inflammatory CNS lesions, antigen-specific T-cell proliferation, and pro-inflammatory cytokines IFNγ and IL-17. Quinpramine is thus an immunoregulatory drug that is a candidate pharmaceutical for MS.",
author = "Singh, {Mahendra P.} and H{\"o}rste, {Gerd Meyer zu} and Wei Hu and Mausberg, {Anne K.} and Cravens, {Petra D.} and Todd Eagar and Stefan L{\"o}ber and Ralf Klingenstein and Peter Gmeiner and Carsten Korth and Kieseier, {Bernd C.} and Olaf St{\"u}ve",
note = "Funding Information: C.K. was supported by grants from the BMBF and the EU Research Commission (Neuroprion), C.K. and P.G. from the VW Foundation. O.S. was supported by a Start-up grant from the Dallas VA Research Corporation, a New Investigator Award grant from VISN 17, Department of Veterans Affairs, a Merit Award from the Department of Veterans Affairs, and a grant from the Viragh Foundation. G.M.z.H. was supported in part by a grant from the Fritz-Thyssen Foundation and the research commission of the University of D{\"u}sseldorf.",
year = "2009",
month = feb,
doi = "10.1016/j.expneurol.2008.10.001",
language = "English (US)",
volume = "215",
pages = "397--400",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",
}