Quod erat faciendum: Sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice

Attila Kumánovics, Anup Madan, Shizhen Qin, Lee Rowen, Leroy Hood, Kirsten Fischer Lindahl

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The H2-D and-Q regions of the mouse major histocompatibility complex (Mhc or H2) have been sequenced from strain 129/SvJ (haplotypebc), revealing a D/Q region different from all other investigated haplotypes, including the closely related b haplotype. The 300-kb class I-rich region consists of the classical class I, H2-D, and 11 non-classical class I genes. The Q region was formed by two series of tandem duplications. Comparison of the segment between the D and Q1 genes with the H2-K region provides evidence that class I genes were translocated from the K region to the D region, and gives a new explanation for the weak locus specificity of the H-K and H2-Dalleles.

Original languageEnglish (US)
Pages (from-to)479-489
Number of pages11
JournalImmunogenetics
Volume54
Issue number7
DOIs
StatePublished - Nov 7 2002

Keywords

  • Class I genes
  • Evolution
  • Gene duplication
  • H2-K region
  • Major histocompatibility complex

ASJC Scopus subject areas

  • Immunology
  • Genetics

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    Kumánovics, A., Madan, A., Qin, S., Rowen, L., Hood, L., & Lindahl, K. F. (2002). Quod erat faciendum: Sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice. Immunogenetics, 54(7), 479-489. https://doi.org/10.1007/s00251-002-0494-0