Abstract
The H2-D and-Q regions of the mouse major histocompatibility complex (Mhc or H2) have been sequenced from strain 129/SvJ (haplotypebc), revealing a D/Q region different from all other investigated haplotypes, including the closely related b haplotype. The 300-kb class I-rich region consists of the classical class I, H2-D, and 11 non-classical class I genes. The Q region was formed by two series of tandem duplications. Comparison of the segment between the D and Q1 genes with the H2-K region provides evidence that class I genes were translocated from the K region to the D region, and gives a new explanation for the weak locus specificity of the H-K and H2-Dalleles.
Original language | English (US) |
---|---|
Pages (from-to) | 479-489 |
Number of pages | 11 |
Journal | Immunogenetics |
Volume | 54 |
Issue number | 7 |
DOIs | |
State | Published - 2002 |
Keywords
- Class I genes
- Evolution
- Gene duplication
- H2-K region
- Major histocompatibility complex
ASJC Scopus subject areas
- Immunology
- Genetics