Quorum Sensing and the Gut Microbiome

Angel G. Jimenez, Vanessa Sperandio

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations


The GI tract is a complex environment heavily affected by both host and microbial processes. The microbiota plays essential functions in maintaining human health by providing the host with nutrients, promoting maturation of the immune system, and preventing enteric infections. These activities depend on effective communication from the host, the microbiota, and between them. This exchange of information among bacteria and between bacteria and the host is known as quorum sensing, interspecies and interkingdom signaling, respectively. This communication relies on host- and microbiota-produced chemicals that range from nutrients to signaling molecules. Insults that disturb the stability of these interactions by altering the structure of the microbiota or silencing this chemical communication have been implicated in various diseased states. In this article, we explore relevant classes of molecules produced or altered by the host, the microbiota, or enteric pathogens that cause transcriptional changes important for the colonization of the gut environment.

Original languageEnglish (US)
Title of host publicationQuorum Sensing
Subtitle of host publicationMolecular Mechanism and Biotechnological Application
Number of pages19
ISBN (Electronic)9780128149065
ISBN (Print)9780128149058
StatePublished - Apr 6 2019


  • Enterohemorrhagic E. coli (EHEC)
  • Microbiota
  • Nutrient signaling
  • QseC
  • Quorum sensing
  • Salmonella

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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