Quorum sensing by enteric pathogens

Melissa M. Kendall, Vanessa Sperandio

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: This review presents advances in our understanding of how pathogenic, enteric bacteria use quorum sensing to regulate several traits that allow them to establish and maintain infection in their host, including motility, biofilm formation, and virulence-specific genes. RECENT FINDINGS: Quorum sensing in enteric bacteria has been elusive for a long time. Recent data indicate that enteric bacteria use several quorum-sensing mechanisms including the LuxR-I quorum-sensing system, the LuxS/AI-2 system, and the AI-3/epinephrine/norepinephrine system to assess their environment and to recognize the host environment. These systems allow bacteria to communicate across species boundaries, and the AI-3/epinephrine/norepinephrine system is involved in interkingdom signaling. SUMMARY: Recent developments in our understanding of the molecular and biochemical mechanisms involved in quorum sensing as well as the chemical signal(s) to which bacteria respond and their corresponding physiological responses will improve our understanding of bacterial pathogenesis and microbial flora-host interactions, and potentially lead to novel strategies for combating infection.

Original languageEnglish (US)
Pages (from-to)10-15
Number of pages6
JournalCurrent Opinion in Gastroenterology
Volume23
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Quorum Sensing
Enterobacteriaceae
Epinephrine
Norepinephrine
Bacteria
Biofilms
Infection
Virulence
Genes

Keywords

  • AI-3
  • Escherichia coli
  • LuxS
  • Quorum sensing
  • Salmonella
  • Yersinia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Quorum sensing by enteric pathogens. / Kendall, Melissa M.; Sperandio, Vanessa.

In: Current Opinion in Gastroenterology, Vol. 23, No. 1, 01.2007, p. 10-15.

Research output: Contribution to journalArticle

Kendall, Melissa M. ; Sperandio, Vanessa. / Quorum sensing by enteric pathogens. In: Current Opinion in Gastroenterology. 2007 ; Vol. 23, No. 1. pp. 10-15.
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