Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost, Josephine R. Chandler, Joshua A V Blodgett, Patricia S. Lima, Breck A. Duerkop, Ken Ichi Oinuma, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalOrganic Letters
Volume12
Issue number4
DOIs
StatePublished - Feb 19 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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    Seyedsayamdost, M. R., Chandler, J. R., Blodgett, J. A. V., Lima, P. S., Duerkop, B. A., Oinuma, K. I., Peter Greenberg, E., & Clardy, J. (2010). Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264. Organic Letters, 12(4), 716-719. https://doi.org/10.1021/ol902751x