Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264

Mohammad R. Seyedsayamdost, Josephine R. Chandler, Joshua A V Blodgett, Patricia S. Lima, Breck A. Duerkop, Ken Ichi Oinuma, E. Peter Greenberg, Jon Clardy

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

(Figure Presented) Bacterial acyl-homoserlne lactones upregulated an uncharacterlzed gene cluster (bta) In Burkholderla thallandensls E264 to produce an uncharacterlzed polar antibiotic. The antibiotic Is Identified as a mixture of four bactobollns. Annotation of the bta cluster allows us to propose a blosynthetlc scheme for bactobolln and reveals unusual enzymatic reactions for further study.

Original languageEnglish (US)
Pages (from-to)716-719
Number of pages4
JournalOrganic Letters
Volume12
Issue number4
DOIs
StatePublished - Feb 19 2010

Fingerprint

Burkholderia
Quorum Sensing
antibiotics
Anti-Bacterial Agents
annotations
Lactones
Multigene Family
genes
Genes
bactobolin

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Seyedsayamdost, M. R., Chandler, J. R., Blodgett, J. A. V., Lima, P. S., Duerkop, B. A., Oinuma, K. I., ... Clardy, J. (2010). Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264. Organic Letters, 12(4), 716-719. https://doi.org/10.1021/ol902751x

Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264. / Seyedsayamdost, Mohammad R.; Chandler, Josephine R.; Blodgett, Joshua A V; Lima, Patricia S.; Duerkop, Breck A.; Oinuma, Ken Ichi; Peter Greenberg, E.; Clardy, Jon.

In: Organic Letters, Vol. 12, No. 4, 19.02.2010, p. 716-719.

Research output: Contribution to journalArticle

Seyedsayamdost, MR, Chandler, JR, Blodgett, JAV, Lima, PS, Duerkop, BA, Oinuma, KI, Peter Greenberg, E & Clardy, J 2010, 'Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264', Organic Letters, vol. 12, no. 4, pp. 716-719. https://doi.org/10.1021/ol902751x
Seyedsayamdost MR, Chandler JR, Blodgett JAV, Lima PS, Duerkop BA, Oinuma KI et al. Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264. Organic Letters. 2010 Feb 19;12(4):716-719. https://doi.org/10.1021/ol902751x
Seyedsayamdost, Mohammad R. ; Chandler, Josephine R. ; Blodgett, Joshua A V ; Lima, Patricia S. ; Duerkop, Breck A. ; Oinuma, Ken Ichi ; Peter Greenberg, E. ; Clardy, Jon. / Quorum-sensing-regulated bActobolin Production by burkholderia thailandensis E264. In: Organic Letters. 2010 ; Vol. 12, No. 4. pp. 716-719.
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