Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults

Mahesh J. Patel, Bryan C. Batch, Laura P. Svetkey, James R. Bain, Christy Boling Turer, Carol Haynes, Michael J. Muehlbauer, Robert D. Stevens, Christopher B. Newgard, Svati H. Shah

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33 Scopus citations

Abstract

In overweight/obese individuals, cardiometabolic risk factors differ by race and sex categories. Small-molecule metabolites and metabolic hormone levels might also differ across these categories and contribute to risk factor heterogeneity. To explore this possibility, we performed a cross-sectional analysis of fasting plasma levels of 69 small-molecule metabolites and 13 metabolic hormones in 500 overweight/obese adults who participated in the Weight Loss Maintenance trial. Principal-components analysis (PCA) was used for reduction of metabolite data. Race and sex-stratified comparisons of metabolite factors and metabolic hormones were performed. African Americans represented 37.4% of the study participants, and females 63.0%. Of thirteen metabolite factors identified, three differed by race and sex: levels of factor 3 (branched-chain amino acids and related metabolites, p<0.0001), factor 6 (long-chain acylcarnitines, p<0.01), and factor 2 (medium-chain dicarboxylated acylcarnitines, p<0.0001) were higher in males vs. females; factor 6 levels were higher in Caucasians vs. African Americans (p<0.0001). Significant differences were also observed in hormones regulating body weight homeostasis. Among overweight/obese adults, there are significant race and sex differences in small-molecule metabolites and metabolic hormones; these differences may contribute to risk factor heterogeneity across race and sex subgroups and should be considered in future investigations with circulating metabolites and metabolic hormones.

Original languageEnglish (US)
Pages (from-to)627-635
Number of pages9
JournalOMICS A Journal of Integrative Biology
Volume17
Issue number12
DOIs
StatePublished - Dec 1 2013

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ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics

Cite this

Patel, M. J., Batch, B. C., Svetkey, L. P., Bain, J. R., Turer, C. B., Haynes, C., Muehlbauer, M. J., Stevens, R. D., Newgard, C. B., & Shah, S. H. (2013). Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults. OMICS A Journal of Integrative Biology, 17(12), 627-635. https://doi.org/10.1089/omi.2013.0031