Racial and ethnic disparities in a national cohort of ampullary cancer patients

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Objectives: Racial and ethnic variations have been described in the different malignancies, but no such data exists for ampullary cancer. The aim of this study was to present an updated report on the epidemiology, treatment patterns, and survival of a national cohort of ampullary cancer patients. Methods: Patients diagnosed with ampullary cancer between 2004 and 2014 were identified in the National Cancer Database. Overall survival was estimated and compared between racial/ethnic groups using the log-rank test. Results: A total of 14 879 patients were identified; 78% of the patients were White, 9% Hispanic, 8% Black, and 5% Asian. We noted significant differences in disease presentation, socioeconomic status, and outcomes. Blacks had the lowest median overall survival at 18.9 months followed by Whites at 23.9 months, Hispanics at 32.7 months, and Asians at 37.4 months. On a multivariate Cox proportional-hazards model, being Black was associated with worse survival compared to being White while being Asian and Hispanic were associated with better survival. Conclusions: Overall survival of ampullary cancer patients was independently associated with race and ethnicity. Further studies are needed to clarify whether these disparities are primarily due to socioeconomic status or biologic factors.

Original languageEnglish (US)
Pages (from-to)220-227
Number of pages8
JournalJournal of Surgical Oncology
Volume117
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Survival
Hispanic Americans
Neoplasms
Social Class
Biological Factors
Proportional Hazards Models
Ethnic Groups
Epidemiology
Databases
Therapeutics

Keywords

  • ampullary cancer
  • ampullary carcinoma
  • disparity
  • ethnicity
  • race

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

@article{5569e5c5f1d64b6fba09fa56af576db3,
title = "Racial and ethnic disparities in a national cohort of ampullary cancer patients",
abstract = "Background and Objectives: Racial and ethnic variations have been described in the different malignancies, but no such data exists for ampullary cancer. The aim of this study was to present an updated report on the epidemiology, treatment patterns, and survival of a national cohort of ampullary cancer patients. Methods: Patients diagnosed with ampullary cancer between 2004 and 2014 were identified in the National Cancer Database. Overall survival was estimated and compared between racial/ethnic groups using the log-rank test. Results: A total of 14 879 patients were identified; 78{\%} of the patients were White, 9{\%} Hispanic, 8{\%} Black, and 5{\%} Asian. We noted significant differences in disease presentation, socioeconomic status, and outcomes. Blacks had the lowest median overall survival at 18.9 months followed by Whites at 23.9 months, Hispanics at 32.7 months, and Asians at 37.4 months. On a multivariate Cox proportional-hazards model, being Black was associated with worse survival compared to being White while being Asian and Hispanic were associated with better survival. Conclusions: Overall survival of ampullary cancer patients was independently associated with race and ethnicity. Further studies are needed to clarify whether these disparities are primarily due to socioeconomic status or biologic factors.",
keywords = "ampullary cancer, ampullary carcinoma, disparity, ethnicity, race",
author = "Ibrahim Nassour and Mokdad, {Ali A.} and Minter, {Rebecca M.} and Polanco, {Patricio M.} and Augustine, {Mathew M.} and Mansour, {John C.} and Porembka, {Matthew R.} and Wang, {Sam C.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1002/jso.24835",
language = "English (US)",
volume = "117",
pages = "220--227",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - Racial and ethnic disparities in a national cohort of ampullary cancer patients

AU - Nassour, Ibrahim

AU - Mokdad, Ali A.

AU - Minter, Rebecca M.

AU - Polanco, Patricio M.

AU - Augustine, Mathew M.

AU - Mansour, John C.

AU - Porembka, Matthew R.

AU - Wang, Sam C.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Background and Objectives: Racial and ethnic variations have been described in the different malignancies, but no such data exists for ampullary cancer. The aim of this study was to present an updated report on the epidemiology, treatment patterns, and survival of a national cohort of ampullary cancer patients. Methods: Patients diagnosed with ampullary cancer between 2004 and 2014 were identified in the National Cancer Database. Overall survival was estimated and compared between racial/ethnic groups using the log-rank test. Results: A total of 14 879 patients were identified; 78% of the patients were White, 9% Hispanic, 8% Black, and 5% Asian. We noted significant differences in disease presentation, socioeconomic status, and outcomes. Blacks had the lowest median overall survival at 18.9 months followed by Whites at 23.9 months, Hispanics at 32.7 months, and Asians at 37.4 months. On a multivariate Cox proportional-hazards model, being Black was associated with worse survival compared to being White while being Asian and Hispanic were associated with better survival. Conclusions: Overall survival of ampullary cancer patients was independently associated with race and ethnicity. Further studies are needed to clarify whether these disparities are primarily due to socioeconomic status or biologic factors.

AB - Background and Objectives: Racial and ethnic variations have been described in the different malignancies, but no such data exists for ampullary cancer. The aim of this study was to present an updated report on the epidemiology, treatment patterns, and survival of a national cohort of ampullary cancer patients. Methods: Patients diagnosed with ampullary cancer between 2004 and 2014 were identified in the National Cancer Database. Overall survival was estimated and compared between racial/ethnic groups using the log-rank test. Results: A total of 14 879 patients were identified; 78% of the patients were White, 9% Hispanic, 8% Black, and 5% Asian. We noted significant differences in disease presentation, socioeconomic status, and outcomes. Blacks had the lowest median overall survival at 18.9 months followed by Whites at 23.9 months, Hispanics at 32.7 months, and Asians at 37.4 months. On a multivariate Cox proportional-hazards model, being Black was associated with worse survival compared to being White while being Asian and Hispanic were associated with better survival. Conclusions: Overall survival of ampullary cancer patients was independently associated with race and ethnicity. Further studies are needed to clarify whether these disparities are primarily due to socioeconomic status or biologic factors.

KW - ampullary cancer

KW - ampullary carcinoma

KW - disparity

KW - ethnicity

KW - race

UR - http://www.scopus.com/inward/record.url?scp=85042518156&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042518156&partnerID=8YFLogxK

U2 - 10.1002/jso.24835

DO - 10.1002/jso.24835

M3 - Article

VL - 117

SP - 220

EP - 227

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 2

ER -