Racial differences in responses to therapy with interferon in chronic hepatitis C

K. Rajender Reddy, Jay H. Hoofnagle, Myron J. Tong, William M. Lee, Paul Pockros, E. Jenny Heathcote, Donald Albert, Tenshang Joh

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264 Scopus citations

Abstract

The likelihood of a sustained response to a course of interferon in patients with chronic hepatitis C correlates with several clinical and viral factors, including age, viral genotype and initial levels of hepatitis C virus (HCV) RNA in serum. The role of race and ethnicity has not been assessed. We evaluated the association of race with response to interferon in a large randomized, controlled trial using either consensus interferon (9 μg) or interferon alfa-2b (3 million units) given three times weekly for 24 weeks. African-American patients participating in the study were similar to white patients in mean age (43 vs. 42 years) and baseline levels of HCV RNA (3.6 vs. 3.0 million copies/mL) but had lower rates of cirrhosis (5% vs. 12%) and more frequently had viral genotype 1 (88% vs. 66%: P = .004). Most strikingly, the rates of end-of-treatment and sustained virological responses were lower among the 40 African-American patients (5% and 2%) than among the 380 white patients (33% and 12%) (P = .04 and .07). Rates of response among Hispanic and Asian-American patients were not statistically different than non-Hispanic white patients. Median viral levels decreased by week 24 of therapy by 2.5 logs in white patients (from 3.0 to 0.012 million copies/mL) but by only 0.5 logs among African-American patients (from 3.6 to 1.8 million copies/mL). Thus, there are marked racial differences in virological responses to interferon in hepatitis C that must be considered in assessing trials of interferon therapy and in counseling patients regarding treatment. The differences in response rates are as yet unexplained.

Original languageEnglish (US)
Pages (from-to)787-793
Number of pages7
JournalHepatology
Volume30
Issue number3
DOIs
StatePublished - Sep 7 1999

ASJC Scopus subject areas

  • Hepatology

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    Reddy, K. R., Hoofnagle, J. H., Tong, M. J., Lee, W. M., Pockros, P., Heathcote, E. J., Albert, D., & Joh, T. (1999). Racial differences in responses to therapy with interferon in chronic hepatitis C. Hepatology, 30(3), 787-793. https://doi.org/10.1002/hep.510300319