RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin-1β pathway

Pengrong Lou, Shitao Zou, Zengfu Shang, Chao He, Aidi Gao, Shunyu Hou, Jundong Zhou

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The E3 ubiquitin ligase RAD 18 has been identified as an oncoprotein that exhibits prometastatic properties in various types of cancer; however, the role of RAD18 in cervical cancer (CC) remains unclear. In the present study, it was revealed that increased expression of RAD18 was associated with worse prognosis of patients with CC. Knockdown of endogenous RAD18 suppressed the motility and invasiveness of CC cells, as evaluated by Transwell assays. mRNA sequencing revealed that silencing RAD18 altered the expression profile of proinflammatory mediators, such as interleukin-1β (IL-1β). Furthermore, exogenous IL-1β treatment rescued RAD18-mediated CC cell invasion. These findings indicated an underlying mechanism via which RAD18 promotes CC progression, suggesting that RAD18 may be a potential biomarker and therapeutic target for malignant CC.

Original languageEnglish (US)
Pages (from-to)3415-3423
Number of pages9
JournalMolecular Medicine Reports
Volume20
Issue number4
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • Cervical cancer
  • Interleukin-1β
  • Metastasis
  • RAD18

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Oncology
  • Cancer Research

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