Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis

M. B. Moore, James P McCulley, H. E. Kaufman, J. B. Robin

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Three myopic patients who wore soft contact lenses developed unilateral Acanthamoeba keratitis that presented with unusual infiltrates that appeared to be located along the corneal nerves. These infiltrates were found in the midstroma, beginning paracentrally, and extending to the limbus in a radial pattern. The epithelium overlying these infiltrates was intact. In two patients, the central epithelium had a stippled, almost dendritiform appearance leading to the misdiagnosis of herpes simplex keratitis. Cultures from corneal scrapings of two patients and cultures of a corneal biopsy from one patient, which included an area of presumed neural involvement, grew Acanthamoebae. All three patients used homemade saline solutions (salt tablets dissolved in distilled water). In one patient, Acanthamoebae were found in the contact lens case solution. In our recent experience, Acanthamoebae have also been found in the distilled water bottle and the saline solution made from distilled water and salt tablets in two additional patients with A. keratitis. Distilled water, which is not sterile, has proven to be one potentially avoidable source of A. keratitis in contact lens wearers.

Original languageEnglish (US)
Pages (from-to)1310-1315
Number of pages6
JournalOphthalmology
Volume93
Issue number10
StatePublished - 1986

Fingerprint

Acanthamoeba Keratitis
Acanthamoeba
Water
Sodium Chloride
Tablets
Contact Lens Solutions
Epithelium
Salts
Herpetic Keratitis
Hydrophilic Contact Lens
Contact Lenses
Diagnostic Errors
Biopsy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Moore, M. B., McCulley, J. P., Kaufman, H. E., & Robin, J. B. (1986). Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis. Ophthalmology, 93(10), 1310-1315.

Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis. / Moore, M. B.; McCulley, James P; Kaufman, H. E.; Robin, J. B.

In: Ophthalmology, Vol. 93, No. 10, 1986, p. 1310-1315.

Research output: Contribution to journalArticle

Moore, MB, McCulley, JP, Kaufman, HE & Robin, JB 1986, 'Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis', Ophthalmology, vol. 93, no. 10, pp. 1310-1315.
Moore, M. B. ; McCulley, James P ; Kaufman, H. E. ; Robin, J. B. / Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis. In: Ophthalmology. 1986 ; Vol. 93, No. 10. pp. 1310-1315.
@article{3aff6b04ddcf40e1bb3ab840cd845abb,
title = "Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis",
abstract = "Three myopic patients who wore soft contact lenses developed unilateral Acanthamoeba keratitis that presented with unusual infiltrates that appeared to be located along the corneal nerves. These infiltrates were found in the midstroma, beginning paracentrally, and extending to the limbus in a radial pattern. The epithelium overlying these infiltrates was intact. In two patients, the central epithelium had a stippled, almost dendritiform appearance leading to the misdiagnosis of herpes simplex keratitis. Cultures from corneal scrapings of two patients and cultures of a corneal biopsy from one patient, which included an area of presumed neural involvement, grew Acanthamoebae. All three patients used homemade saline solutions (salt tablets dissolved in distilled water). In one patient, Acanthamoebae were found in the contact lens case solution. In our recent experience, Acanthamoebae have also been found in the distilled water bottle and the saline solution made from distilled water and salt tablets in two additional patients with A. keratitis. Distilled water, which is not sterile, has proven to be one potentially avoidable source of A. keratitis in contact lens wearers.",
author = "Moore, {M. B.} and McCulley, {James P} and Kaufman, {H. E.} and Robin, {J. B.}",
year = "1986",
language = "English (US)",
volume = "93",
pages = "1310--1315",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Radial keratoneuritis as a presenting sign in Acanthamoeba keratitis

AU - Moore, M. B.

AU - McCulley, James P

AU - Kaufman, H. E.

AU - Robin, J. B.

PY - 1986

Y1 - 1986

N2 - Three myopic patients who wore soft contact lenses developed unilateral Acanthamoeba keratitis that presented with unusual infiltrates that appeared to be located along the corneal nerves. These infiltrates were found in the midstroma, beginning paracentrally, and extending to the limbus in a radial pattern. The epithelium overlying these infiltrates was intact. In two patients, the central epithelium had a stippled, almost dendritiform appearance leading to the misdiagnosis of herpes simplex keratitis. Cultures from corneal scrapings of two patients and cultures of a corneal biopsy from one patient, which included an area of presumed neural involvement, grew Acanthamoebae. All three patients used homemade saline solutions (salt tablets dissolved in distilled water). In one patient, Acanthamoebae were found in the contact lens case solution. In our recent experience, Acanthamoebae have also been found in the distilled water bottle and the saline solution made from distilled water and salt tablets in two additional patients with A. keratitis. Distilled water, which is not sterile, has proven to be one potentially avoidable source of A. keratitis in contact lens wearers.

AB - Three myopic patients who wore soft contact lenses developed unilateral Acanthamoeba keratitis that presented with unusual infiltrates that appeared to be located along the corneal nerves. These infiltrates were found in the midstroma, beginning paracentrally, and extending to the limbus in a radial pattern. The epithelium overlying these infiltrates was intact. In two patients, the central epithelium had a stippled, almost dendritiform appearance leading to the misdiagnosis of herpes simplex keratitis. Cultures from corneal scrapings of two patients and cultures of a corneal biopsy from one patient, which included an area of presumed neural involvement, grew Acanthamoebae. All three patients used homemade saline solutions (salt tablets dissolved in distilled water). In one patient, Acanthamoebae were found in the contact lens case solution. In our recent experience, Acanthamoebae have also been found in the distilled water bottle and the saline solution made from distilled water and salt tablets in two additional patients with A. keratitis. Distilled water, which is not sterile, has proven to be one potentially avoidable source of A. keratitis in contact lens wearers.

UR - http://www.scopus.com/inward/record.url?scp=0022507060&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022507060&partnerID=8YFLogxK

M3 - Article

VL - 93

SP - 1310

EP - 1315

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 10

ER -