Radiation-induced bone abnormalities after bone marrow transplantation for childhood leukemia

Barry D. Fletcher, Deborah B. Crom, Robert A. Krance, Larry E. Kun

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


PURPOSE: To identify bone abnormalities related to total-body irradiation (TBI) in long-term survivors of bone marrow transplantation (BMT) for childhood leukemia. MATERIALS AND METHODS: The authors obtained skeletal surveys of 10 survivors of childhood leukemia, ages 5-27 years, who had undergone BMT 7-9 years previously. Pretransplantation 'conditioning' regimens were composed of chemotherapy and TBI in doses of 12 or 14.4 Gy. RESULTS: Of the six survivors who received TBI before age 8 years, five had osteochondromas and three had metaphyseal growth abnormalities. One also had slipped femoral capital epiphysis. Findings in the four remaining patients, who received TBI at ages 12-19 years, were less severe and less clearly related to TBI (mild scoliosis in two cases, avascular necrosis of the femoral condyles in one, and a femoral enchondroma in one). CONCLUSIONS: Skeletal abnormalities, previously recognized as sequelae of local external- beam irradiation in children, may occur in long-term survivors of BMT who have received TBI. Younger patients appear to be at the greatest risk.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
Issue number1
StatePublished - Apr 1994


  • Bone marrow, transplantation
  • Bones, effects of irradiation on
  • Bones, growth and development
  • Leukemia, in infants and children
  • Leukemia, therapy
  • Osteochondroma
  • Radiations, injurious effects, complications of therapeutic radiology

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Radiation-induced bone abnormalities after bone marrow transplantation for childhood leukemia'. Together they form a unique fingerprint.

Cite this