Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells

Hua Liang, Liufu Deng, Byron Burnette, Ralph R. Weichselbaum, Yang Xin Fu

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8+ T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.

Original languageEnglish (US)
Article numbere25668
JournalOncoImmunology
Volume2
Issue number9
DOIs
StatePublished - Dec 18 2013

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Keywords

  • Equilibrium
  • PD-L1
  • Radiation
  • T cells
  • Tumor recurrence

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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