Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells

Hua Liang; Liufu Deng; Byron Burnette; Ralph R. Weichselbaum; Yang Xin Fu

doi:10.4161/onci.25668

Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells

Hua Liang, Liufu Deng, Byron Burnette, Ralph R. Weichselbaum, Yang Xin Fu

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8⁺ T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.

Original language	English (US)
Article number	e25668
Journal	OncoImmunology
Volume	2
Issue number	9
DOIs	https://doi.org/10.4161/onci.25668
State	Published - 2013

Keywords

Equilibrium
PD-L1
Radiation
T cells
Tumor recurrence

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.25668

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title = "Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells",

abstract = "Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8+ T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.",

keywords = "Equilibrium, PD-L1, Radiation, T cells, Tumor recurrence",

author = "Hua Liang and Liufu Deng and Byron Burnette and Weichselbaum, {Ralph R.} and Fu, {Yang Xin}",

note = "Funding Information: Dr Fu and Dr Weichselbaum currently receive grant funding from Bristol Myers Squibb; and Dr Weichselbaum received a one-time consulting fee from Bristol Myers Squibb.",

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AU - Liang, Hua

AU - Deng, Liufu

AU - Burnette, Byron

AU - Weichselbaum, Ralph R.

AU - Fu, Yang Xin

N1 - Funding Information: Dr Fu and Dr Weichselbaum currently receive grant funding from Bristol Myers Squibb; and Dr Weichselbaum received a one-time consulting fee from Bristol Myers Squibb.

PY - 2013

Y1 - 2013

N2 - Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8+ T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.

AB - Despite its efficacy and widespread use, radiation therapy is often associated with local or distal tumor relapse. We have recently found that CD8+ T cells and their cytokines are essential for maintaining irradiated neoplasms under control. In line with this notion, enhancing T-cell functions by means of immune checkpoint inhibitors can tilt the balance toward tumor rejection.

KW - Equilibrium

KW - PD-L1

KW - Radiation

KW - T cells

KW - Tumor recurrence

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Radiation-induced tumor dormancy reflects an equilibrium between the proliferation and T lymphocyte-mediated death of malignant cells

Abstract

Keywords

ASJC Scopus subject areas

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