Radiation response of mammalian tumor cells. i. repair of sublethal damage in vivo

J. A. Belli, G. J. Dicus, F. J. Bonte

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27 Scopus citations

Abstract

To answer certain questions concerning the ability of mammalian tumor cells to repair sublethal radiation damage in vivo, the 2-dose recovery response of the P388 lymphocytic tumor of the DBA/2 mouse was studied as a function of tumor age at the time of the conditioning dose. Aerobic (1-day) and hypoxic (6-day) tumors demonstrated early repair of sublethal damage; the rate of recovery was slower in 6-day tumors. In addition, the maximum degree of recovery in tumors of either age was of the same order of magnitude as the extrapolation numbers observed from single dose-survival curves. Complete recovery, i.e., return of threshold response similar to that observed with nonirradiated cells, occurred within 24 hours after the conditioning dose.

Original languageEnglish (US)
Pages (from-to)673-682
Number of pages10
JournalJournal of the National Cancer Institute
Volume38
Issue number5
DOIs
StatePublished - May 1967

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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