Radio-frequency thermal ablation with NaCl solution injection

Effect of electrical conductivity on tissue heating and coagulation - Phantom and porcine liver study

S. N. Goldberg, M. Ahmed, G. S. Gazelle, J. B. Kruskal, J. C. Huertas, E. F. Halpern, B. S. Oliver, R. E. Lenkinski

Research output: Contribution to journalArticle

222 Citations (Scopus)

Abstract

PURPOSE: To characterize the effects of NaCl concentration on tissue electrical conductivity, radio-frequency (RF) deposition, and heating in phantoms and optimize adjunctive NaCl solution injection for RF ablation in an in vivo model. MATERIALS AND METHODS: RF was applied for 12-15 minutes with internally cooled electrodes. For phantom experiments (n = 51), the NaCl concentration in standardized 5% agar was varied (0%-25.0%). A nonlinear simplex optimization strategy was then used in normal porcine liver (n = 44) to determine optimal pre-RF NaCl solution injection parameters (concentration, 0%-38.5%; volume, 0-25 mL). NaCl concentration and tissue conductivity were correlated with RF energy deposition, tissue heating, and induced coagulation. RESULTS: NaCl concentration had significant but nonlinear effects on electrical conductivity, RF deposition, and heating of agar phantoms (P < .01). Progressively greater heating was observed to 5.0% NaCl, with reduced temperatures at higher concentrations. For in vivo liver, NaCl solution volume and concentration significantly influenced both tissue heating and coagulation (P < .001). Maximum heating 20 mm from the electrode (102.9°C ± 4.3 [SD]) and coagulation (7.1 cm ± 1.1) occurred with injection of 6 mL of 38.5% (saturated) NaCl solution. CONCLUSION: Injection of NaCl solution before RF ablation can increase energy deposition, tissue heating, and induced coagulation, which will likely benefit clinical RF ablation. In normal well-perfused liver, maximum coagulation (7.0 cm) occurs with injection of small volumes of saturated NaCl solution.

Original languageEnglish (US)
Pages (from-to)157-165
Number of pages9
JournalRadiology
Volume219
Issue number1
StatePublished - 2001

Fingerprint

Electric Conductivity
Radio
Heating
Swine
Hot Temperature
Injections
Liver
Agar
Electrodes
Temperature

Keywords

  • Liver neoplasms, therapy
  • Liver, interventional procedures
  • Radiofrequency (RF) ablation

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Radio-frequency thermal ablation with NaCl solution injection : Effect of electrical conductivity on tissue heating and coagulation - Phantom and porcine liver study. / Goldberg, S. N.; Ahmed, M.; Gazelle, G. S.; Kruskal, J. B.; Huertas, J. C.; Halpern, E. F.; Oliver, B. S.; Lenkinski, R. E.

In: Radiology, Vol. 219, No. 1, 2001, p. 157-165.

Research output: Contribution to journalArticle

Goldberg, SN, Ahmed, M, Gazelle, GS, Kruskal, JB, Huertas, JC, Halpern, EF, Oliver, BS & Lenkinski, RE 2001, 'Radio-frequency thermal ablation with NaCl solution injection: Effect of electrical conductivity on tissue heating and coagulation - Phantom and porcine liver study', Radiology, vol. 219, no. 1, pp. 157-165.
Goldberg, S. N. ; Ahmed, M. ; Gazelle, G. S. ; Kruskal, J. B. ; Huertas, J. C. ; Halpern, E. F. ; Oliver, B. S. ; Lenkinski, R. E. / Radio-frequency thermal ablation with NaCl solution injection : Effect of electrical conductivity on tissue heating and coagulation - Phantom and porcine liver study. In: Radiology. 2001 ; Vol. 219, No. 1. pp. 157-165.
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AU - Goldberg, S. N.

AU - Ahmed, M.

AU - Gazelle, G. S.

AU - Kruskal, J. B.

AU - Huertas, J. C.

AU - Halpern, E. F.

AU - Oliver, B. S.

AU - Lenkinski, R. E.

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N2 - PURPOSE: To characterize the effects of NaCl concentration on tissue electrical conductivity, radio-frequency (RF) deposition, and heating in phantoms and optimize adjunctive NaCl solution injection for RF ablation in an in vivo model. MATERIALS AND METHODS: RF was applied for 12-15 minutes with internally cooled electrodes. For phantom experiments (n = 51), the NaCl concentration in standardized 5% agar was varied (0%-25.0%). A nonlinear simplex optimization strategy was then used in normal porcine liver (n = 44) to determine optimal pre-RF NaCl solution injection parameters (concentration, 0%-38.5%; volume, 0-25 mL). NaCl concentration and tissue conductivity were correlated with RF energy deposition, tissue heating, and induced coagulation. RESULTS: NaCl concentration had significant but nonlinear effects on electrical conductivity, RF deposition, and heating of agar phantoms (P < .01). Progressively greater heating was observed to 5.0% NaCl, with reduced temperatures at higher concentrations. For in vivo liver, NaCl solution volume and concentration significantly influenced both tissue heating and coagulation (P < .001). Maximum heating 20 mm from the electrode (102.9°C ± 4.3 [SD]) and coagulation (7.1 cm ± 1.1) occurred with injection of 6 mL of 38.5% (saturated) NaCl solution. CONCLUSION: Injection of NaCl solution before RF ablation can increase energy deposition, tissue heating, and induced coagulation, which will likely benefit clinical RF ablation. In normal well-perfused liver, maximum coagulation (7.0 cm) occurs with injection of small volumes of saturated NaCl solution.

AB - PURPOSE: To characterize the effects of NaCl concentration on tissue electrical conductivity, radio-frequency (RF) deposition, and heating in phantoms and optimize adjunctive NaCl solution injection for RF ablation in an in vivo model. MATERIALS AND METHODS: RF was applied for 12-15 minutes with internally cooled electrodes. For phantom experiments (n = 51), the NaCl concentration in standardized 5% agar was varied (0%-25.0%). A nonlinear simplex optimization strategy was then used in normal porcine liver (n = 44) to determine optimal pre-RF NaCl solution injection parameters (concentration, 0%-38.5%; volume, 0-25 mL). NaCl concentration and tissue conductivity were correlated with RF energy deposition, tissue heating, and induced coagulation. RESULTS: NaCl concentration had significant but nonlinear effects on electrical conductivity, RF deposition, and heating of agar phantoms (P < .01). Progressively greater heating was observed to 5.0% NaCl, with reduced temperatures at higher concentrations. For in vivo liver, NaCl solution volume and concentration significantly influenced both tissue heating and coagulation (P < .001). Maximum heating 20 mm from the electrode (102.9°C ± 4.3 [SD]) and coagulation (7.1 cm ± 1.1) occurred with injection of 6 mL of 38.5% (saturated) NaCl solution. CONCLUSION: Injection of NaCl solution before RF ablation can increase energy deposition, tissue heating, and induced coagulation, which will likely benefit clinical RF ablation. In normal well-perfused liver, maximum coagulation (7.0 cm) occurs with injection of small volumes of saturated NaCl solution.

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