Radioactivity-synchronized fluorescence enhancement using a radionuclide fluorescence-quenched dye

Mikhail Y. Berezin, Kevin Guo, Bao Teng, W. Barry Edwards, Carolyn J. Anderson, Olga Vasalatiy, Amir Gandjbakhche, Gary L. Griffiths, Samuel Achilefu

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


(Chemical Equation Presented) We demonstrate the first evidence of radioactivity-synchronized fluorescence quenching of a near-infrared light-emitting dye by a radionuclide, 64Cu, and subsequent fluorescence enhancement upon 64Cu decay to the daughter isotopes 64Ni and 64Zn. The dynamic switch from high radioactivity and low fluorescence to low radioactivity and high fluorescence is potentially useful for developing complementary multimodal imaging and detection platforms for chemical, environmental, and biomedical applications as well as for unraveling the mechanisms of metal-induced dynamic fluorescence changes.

Original languageEnglish (US)
Pages (from-to)9198-9200
Number of pages3
JournalJournal of the American Chemical Society
Issue number26
StatePublished - Jul 8 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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