Radioimmunodetection of Cutaneous T-Cell Lymphoma with 111In-Labeled T101 Monoclonal Antibody

J. A. Carrasquillo, P. A. Bunn, A. M. Keenan, J. C. Reynolds, R. W. Schroff, K. A. Foon, M. H. Su, A. F. Gazdar, J. L. Mulshine, R. K. Oldham

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109 Scopus citations

Abstract

T101 monoclonal antibody recognizes a pan-T-cell antigen present on normal T cells and also found in high concentrations in cutaneous T-cell lymphoma. We used this antibody, Radio-labeled with 111In, in gamma-camera imaging to detect sites of metastatic cutaneous T-cell lymphoma in 11 patients with advanced disease. In all patients, [111In]T101 concentrated in pathologically or clinically detected nodes, including those in several previously unsuspected nodal regions. Concentrations (per gram of tissue) ranged from 0.01 to 0.03 percent of the injected dose and were consistently 10 to 100 times higher than previously reported on radioimmunodetection. Focal uptake was seen in skin tumors and heavily infiltrated erythroderma but not in skin plaques. The specificity of tumor targeting was documented by control studies with [111In]chloride or [111In]9.2.27 (anti-melanoma) monoclonal antibody. Increasing the T101 dose (1 to 50 mg) altered distribution in nontumor tissues. These studies suggest that imaging with [111In]T101 may be of value in identifying sites of cutaneous T-cell lymphoma. In contrast to the targeting of solid tumors, the mechanism of localization appears to be related to binding to T cells, which can then carry the radioactivity to involved sites. (N Engl J Med 1986; 315:673–80.), Routine pretreatment staging is of considerable importance in defining the natural history, clinical prognosis, and post-treatment evaluation of malignant lymphomas. Numerous staging procedures are required to assess the extent of visceral and nodal disease.1,2 Evaluation of extracutaneous disease in patients with the cutaneous T-cell lymphomas has been particularly difficult because of problems in histologic interpretation of tissue specimens and reluctance to perform invasive procedures in patients with these indolent lymphomas.3,4 Thus, improved, noninvasive staging methods are desirable in evaluating cutaneous T-cell lymphoma. Radioimmunodetection is an in vivo diagnostic approach that employs antitumor antibodies as carriers of radioactivity to tumor cells.

Original languageEnglish (US)
Pages (from-to)673-680
Number of pages8
JournalNew England Journal of Medicine
Volume315
Issue number11
DOIs
StatePublished - Sep 11 1986

ASJC Scopus subject areas

  • Medicine(all)

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    Carrasquillo, J. A., Bunn, P. A., Keenan, A. M., Reynolds, J. C., Schroff, R. W., Foon, K. A., Su, M. H., Gazdar, A. F., Mulshine, J. L., & Oldham, R. K. (1986). Radioimmunodetection of Cutaneous T-Cell Lymphoma with 111In-Labeled T101 Monoclonal Antibody. New England Journal of Medicine, 315(11), 673-680. https://doi.org/10.1056/NEJM198609113151104