Radioimmunological study of rat uterine extract

J. P. Descoteaux, V. C. Stevens, L. R. Beck, S. P. Pakes

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Abstract

A radioassay was used to demonstrate the high affinity of a crude rat uterine extract for tritiated estradiol-17B. Although no other chemical procedures were employed to further characterize the extract, it may contain the estrogen binding protein isolated by others. The isolate was antigenic in rabbits and administration of immune serum to female rats significantly lowered the in vitro retention of tritiated estradiol-17B in the rat uterus. It is thought that this immune serum could be successfully used to study the estrogen binding activity of rat uterus.

Original languageEnglish (US)
Pages (from-to)139-142
Number of pages4
JournalCanadian Journal of Comparative Medicine
Volume42
Issue number1
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • veterinary(all)

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Descoteaux, J. P., Stevens, V. C., Beck, L. R., & Pakes, S. P. (1978). Radioimmunological study of rat uterine extract. Canadian Journal of Comparative Medicine, 42(1), 139-142.