Radiolabled polymeric nanoparticles for imaging alzheimer's plaques in a mouse model of alzheimer's disease (AD)

P. V. Kulkarni, C. R. Roney, V. Arora, M. Bennett, P. P. Antich, F. J. Bonte

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We have shown that, clioquinol (CQ) (5-chloro-7-iodo-8 hydroxy quinoline) can be radioiodinated and has rapid brain uptake and fast clearance from the blood and brain in normal mice. In order to enhance its brain uptake and retard the fast brain clearance, we incorporated it into butylpolycyanoacrylate (BCA) nanoparticles (NP). Selective localization of 125I CQ BCA nanoparticles was observed in autoradiograph of Alzheimer's Disease (AD) patient's postmortem brain sections. We studied its biodistribution in normal mice and experimental AD mice. AD lesions were created by administration of preformed aggregates of A-beta peptide (A□42) into hippocampus of mice using a stereotactic device. Biodistribution and ex-vivo autoradiography of the brains of mice injected with 125I CQ BCA nanoparticles showed that: 1. nanoparticles enhanced (1.5-2 times) the brain delivery of the 125I-CQ 2. Autoradiograph of AD brain sections showed localized uptake of the radiotracer and 3. experimental animal brains had positive autoradiogram compared to the control animals and animals injected with the free drug. Our data indicate that butyl polycyanoacrylate nanoparticles may be useful drug delivery vehicles for imaging AD with amyloid specific dyes.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
PublisherAmerican Institute of Physics
Pages492-495
Number of pages4
Volume1099
DOIs
StatePublished - 2009
Event20th International Conference on the Application of Accelerators in Research and Industry, CAARI 2008 - Fort Worth, TX, United States
Duration: Aug 10 2008Aug 15 2008

Other

Other20th International Conference on the Application of Accelerators in Research and Industry, CAARI 2008
CountryUnited States
CityFort Worth, TX
Period8/10/088/15/08

Keywords

  • Alzheimer's imaging
  • Autoradiography
  • Clioquinol
  • Nanoparticles
  • Radiolabel

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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    Kulkarni, P. V., Roney, C. R., Arora, V., Bennett, M., Antich, P. P., & Bonte, F. J. (2009). Radiolabled polymeric nanoparticles for imaging alzheimer's plaques in a mouse model of alzheimer's disease (AD). In AIP Conference Proceedings (Vol. 1099, pp. 492-495). American Institute of Physics. https://doi.org/10.1063/1.3120081