Radiological Estimation of Intracranial Blood Volume and Occurrence of Hydrocephalus Determines Stress-Induced Hyperglycemia After Aneurysmal Subarachnoid Hemorrhage

Joshua A. Santucci, Stephen R. Ross, John C. Greenert, Faranak Aghaei, Lance Ford, Kimberly M. Hollabaugh, Benjamin O. Cornwell, Dee H. Wu, Bin Zheng, Bradley N. Bohnstedt, Bappaditya Ray

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Acute phase after aneurysmal subarachnoid hemorrhage (aSAH) is associated with several metabolic derangements including stress-induced hyperglycemia (SIH). The present study is designed to identify objective radiological determinants for SIH to better understand its contributory role in clinical outcomes after aSAH. A computer-aided detection tool was used to segment admission computed tomography (CT) images of aSAH patients to estimate intracranial blood and cerebrospinal fluid volumes. Modified Graeb score (mGS) was used as a semi-quantitative measure to estimate degree of hydrocephalus. The relationship between glycemic gap (GG) determined SIH, mGS, and estimated intracranial blood and cerebrospinal fluid volumes were evaluated using linear regression. Ninety-four [94/187 (50.3%)] among the study cohort had SIH (defined as GG > 26.7 mg/dl). Patients with SIH had 14.3 ml/1000 ml more intracranial blood volume as compared to those without SIH [39.6 ml (95% confidence interval, CI, 33.6 to 45.5) vs. 25.3 ml (95% CI 20.6 to 29.9), p = 0.0002]. Linear regression analysis of mGS with GG showed each unit increase in mGS resulted in 1.2 mg/dl increase in GG [p = 0.002]. Patients with SIH had higher mGS [median 4.0, interquartile range, IQR 2.0–7.0] as compared to those without SIH [median 2.0, IQR 0.0–6.0], p = 0.002. Patients with third ventricular blood on admission CT scan were more likely to develop SIH [67/118 (56.8%) vs. 27/69 (39.1%), p = 0.023]. Hence, the present study, using unbiased SIH definition and objective CT scan parameters, reports “dose-dependent” radiological features resulting in SIH. Such findings allude to a brain injury-stress response-neuroendocrine axis in etiopathogenesis of SIH.

Original languageEnglish (US)
Pages (from-to)327-337
Number of pages11
JournalTranslational Stroke Research
Volume10
Issue number3
DOIs
StatePublished - Jun 15 2019
Externally publishedYes

Keywords

  • Delayed cerebral ischemia
  • Hemorrhagic stroke
  • Hydrocephalus
  • Hyperglycemia
  • Shunt

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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    Santucci, J. A., Ross, S. R., Greenert, J. C., Aghaei, F., Ford, L., Hollabaugh, K. M., Cornwell, B. O., Wu, D. H., Zheng, B., Bohnstedt, B. N., & Ray, B. (2019). Radiological Estimation of Intracranial Blood Volume and Occurrence of Hydrocephalus Determines Stress-Induced Hyperglycemia After Aneurysmal Subarachnoid Hemorrhage. Translational Stroke Research, 10(3), 327-337. https://doi.org/10.1007/s12975-018-0646-7