Radiotherapy for cervical spine metastases in breast cancer patients

Federico Ampil, Gloria Caldito, Joel Thibodeaux, Guillermo Sangster, Roxana Baluna

Research output: Contribution to journalArticle

Abstract

Background: Although cervical spine metastasis in breast cancer patients is the least frequent of metastatic disease to the spinal column, it is nonetheless a clinically important source of morbidity and mortality. The aim of this study was to describe our radiotherapeutic experience of this particular neoplastic complication. Methods: The records of 1,226 women with carcinoma of the breast between 1990 and 2005 were assessed retrospectively for the development of metastatic disease in the cervical spine. Sixteen of these patients underwent palliative radiotherapy for cervical spine metastasis of breast carcinoma origin. Results: The mean interval prior to the appearance of cervical spine metastases was 38.9 months. The most frequently observed clinical manifestations were neck pain (56%) and limb paresis/palsy (38%). Among the evaluable people, the complete and absent subjective response rates were 86 and 14%, respectively; the corresponding objective response rates were both 50%. Other osseous and extra-osseous metastatic lesions were present in the majority of cases (69%). The overall 1-year survival rate was 19%, and median survival was 3 months. Conclusion: Cervical spine metastases in women with breast cancer are associated with a limited chance for survival. Symptomatic patients overall derive palliation from conventional treatment.

Original languageEnglish (US)
Pages (from-to)527-531
Number of pages5
JournalEuropean Journal of Orthopaedic Surgery and Traumatology
Volume20
Issue number7
DOIs
StatePublished - Oct 2010

Fingerprint

Spine
Radiotherapy
Breast Neoplasms
Neoplasm Metastasis
Survival
Neck Pain
Paresis
Paralysis
Survival Rate
Extremities
Morbidity
Mortality
Therapeutics

Keywords

  • Breast cancer
  • Cervical spine
  • Metastasis
  • Radiotherapy

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Radiotherapy for cervical spine metastases in breast cancer patients. / Ampil, Federico; Caldito, Gloria; Thibodeaux, Joel; Sangster, Guillermo; Baluna, Roxana.

In: European Journal of Orthopaedic Surgery and Traumatology, Vol. 20, No. 7, 10.2010, p. 527-531.

Research output: Contribution to journalArticle

Ampil, Federico ; Caldito, Gloria ; Thibodeaux, Joel ; Sangster, Guillermo ; Baluna, Roxana. / Radiotherapy for cervical spine metastases in breast cancer patients. In: European Journal of Orthopaedic Surgery and Traumatology. 2010 ; Vol. 20, No. 7. pp. 527-531.
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