Rag GTPases

Jenna L. Jewell, Kun Liang Guan

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Rag GTPases appear to reside on the lysosome and link amino acid stimulation to mTOR complex 1 (mTORC1) activation. mTORC1 couples nutrient availability to cell growth. Dysregulation of mTORC1 is implicated in a number of human diseases, including cancer and diabetes. In response to amino acid availability the Rag GTPases are regulated by the Ragulator and GATOR complexes, which are a guanine nucleotide exchange factor (GEF) and GTPase activating protein (GAP), respectively. Here we review the current knowledge of Rag GTPases, with emphasis on amino acid-dependent regulation of mTORC1.

Original languageEnglish (US)
Title of host publicationRas Superfamily Small G Proteins
Subtitle of host publicationBiology and Mechanisms 2: Transport
PublisherSpringer International Publishing
Pages277-292
Number of pages16
ISBN (Electronic)9783709118061
ISBN (Print)3319077600, 9783709118054
DOIs
StatePublished - May 1 2014

Keywords

  • amino acids
  • Gator
  • lysosome
  • mTORC1
  • Rag GTPases
  • Ragulator
  • v-ATPase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Jewell, J. L., & Guan, K. L. (2014). Rag GTPases. In Ras Superfamily Small G Proteins: Biology and Mechanisms 2: Transport (pp. 277-292). Springer International Publishing. https://doi.org/10.1007/978-3-319-07761-1_12