Ral GTPases and cancer: Linchpin support of the tumorigenic platform

Brian O. Bodemann, Michael A. White

Research output: Contribution to journalReview article

174 Scopus citations

Abstract

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

Original languageEnglish (US)
Pages (from-to)133-140
Number of pages8
JournalNature Reviews Cancer
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2008

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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