Ral GTPases and cancer: Linchpin support of the tumorigenic platform

Brian O. Bodemann; Michael A. White

doi:10.1038/nrc2296

Ral GTPases and cancer: Linchpin support of the tumorigenic platform

Brian O. Bodemann, Michael A. White

Research output: Contribution to journal › Review article › peer-review

197 Scopus citations

Abstract

A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

Original language	English (US)
Pages (from-to)	133-140
Number of pages	8
Journal	Nature Reviews Cancer
Volume	8
Issue number	2
DOIs	https://doi.org/10.1038/nrc2296
State	Published - Feb 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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abstract = "A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.",

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AB - A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.

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Ral GTPases and cancer: Linchpin support of the tumorigenic platform

Abstract

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