RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

Yuchen Chien; Michael A. White

doi:10.1038/sj.embor.embor899

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

Yuchen Chien, Michael A. White

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remarkably, this task is divided between these highly homologous isoforms. RALB is specifically required for survival of tumour cells but not normal cells. RALA is dispensable for survival, but is required for anchorage-independent proliferation. Reducing the 'oncogenic burden' in human tumour cells relieves the sensitivity to loss of RALB. These observations establish RAL GTPases as crucial components of the cellular machinery that are exploited by factors that drive oncogenic transformation.

Original language	English (US)
Pages (from-to)	800-806
Number of pages	7
Journal	EMBO Reports
Volume	4
Issue number	8
DOIs	https://doi.org/10.1038/sj.embor.embor899
State	Published - Aug 1 2003

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics

Access to Document

10.1038/sj.embor.embor899

Cite this

@article{4521ff9f217d42e0b8cef8aa78928e1d,

title = "RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival",

abstract = "The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remarkably, this task is divided between these highly homologous isoforms. RALB is specifically required for survival of tumour cells but not normal cells. RALA is dispensable for survival, but is required for anchorage-independent proliferation. Reducing the 'oncogenic burden' in human tumour cells relieves the sensitivity to loss of RALB. These observations establish RAL GTPases as crucial components of the cellular machinery that are exploited by factors that drive oncogenic transformation.",

author = "Yuchen Chien and White, {Michael A.}",

year = "2003",

month = aug,

day = "1",

doi = "10.1038/sj.embor.embor899",

language = "English (US)",

volume = "4",

pages = "800--806",

journal = "EMBO Reports",

issn = "1469-221X",

publisher = "Nature Publishing Group",

number = "8",

}

TY - JOUR

T1 - RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

AU - Chien, Yuchen

AU - White, Michael A.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remarkably, this task is divided between these highly homologous isoforms. RALB is specifically required for survival of tumour cells but not normal cells. RALA is dispensable for survival, but is required for anchorage-independent proliferation. Reducing the 'oncogenic burden' in human tumour cells relieves the sensitivity to loss of RALB. These observations establish RAL GTPases as crucial components of the cellular machinery that are exploited by factors that drive oncogenic transformation.

AB - The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remarkably, this task is divided between these highly homologous isoforms. RALB is specifically required for survival of tumour cells but not normal cells. RALA is dispensable for survival, but is required for anchorage-independent proliferation. Reducing the 'oncogenic burden' in human tumour cells relieves the sensitivity to loss of RALB. These observations establish RAL GTPases as crucial components of the cellular machinery that are exploited by factors that drive oncogenic transformation.

UR - http://www.scopus.com/inward/record.url?scp=0042353628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042353628&partnerID=8YFLogxK

U2 - 10.1038/sj.embor.embor899

DO - 10.1038/sj.embor.embor899

M3 - Article

C2 - 12856001

AN - SCOPUS:0042353628

SN - 1469-221X

VL - 4

SP - 800

EP - 806

JO - EMBO Reports

JF - EMBO Reports

IS - 8

ER -

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this