RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

Yuchen Chien, Michael A. White

Research output: Contribution to journalArticle

152 Scopus citations

Abstract

The monomeric RAL (RAS-like) GTPases have been indirectly implicated in mitogenic regulation and cell transformation. Here, we show that RALA and RALB collaborate to maintain tumorigenicity through regulation of both proliferation and survival. Remarkably, this task is divided between these highly homologous isoforms. RALB is specifically required for survival of tumour cells but not normal cells. RALA is dispensable for survival, but is required for anchorage-independent proliferation. Reducing the 'oncogenic burden' in human tumour cells relieves the sensitivity to loss of RALB. These observations establish RAL GTPases as crucial components of the cellular machinery that are exploited by factors that drive oncogenic transformation.

Original languageEnglish (US)
Pages (from-to)800-806
Number of pages7
JournalEMBO Reports
Volume4
Issue number8
DOIs
StatePublished - Aug 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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