Raman and surface-enhanced Raman spectroscopy for renal condition monitoring

Jingting Li, Ming Li, Yong Du, Greggy M. Santos, Chandra Mohan, Wei Chuan Shih

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Non- and minimally-invasive techniques can provide advantages in the monitoring and clinical diagnostics in renal diseases. Although renal biopsy may be useful in establishing diagnosis in several diseases, it is an invasive approach and impractical for longitudinal disease monitoring. To address this unmet need, we have developed two techniques based on Raman spectroscopy. First, we have investigated the potential of diagnosing and staging nephritis by analyzing kidney tissue Raman spectra using multivariate techniques. Secondly, we have developed a urine creatinine sensor based on surface-enhanced Raman spectroscopy with performance near commercial assays which require relatively laborious sample preparation and longer time.

Original languageEnglish (US)
Title of host publicationBiomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
PublisherSPIE
Volume9704
ISBN (Electronic)9781628419382
DOIs
StatePublished - 2016
EventBiomedical Vibrational Spectroscopy 2016: Advances in Research and Industry - San Francisco, United States
Duration: Feb 13 2016Feb 14 2016

Other

OtherBiomedical Vibrational Spectroscopy 2016: Advances in Research and Industry
CountryUnited States
CitySan Francisco
Period2/13/162/14/16

Keywords

  • creatinine
  • linear discriminant analysis
  • nanoporous gold
  • principal component analysis
  • SERS

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Li, J., Li, M., Du, Y., Santos, G. M., Mohan, C., & Shih, W. C. (2016). Raman and surface-enhanced Raman spectroscopy for renal condition monitoring. In Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry (Vol. 9704). [97040T] SPIE. https://doi.org/10.1117/12.2212573