Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis

Gil I. Wolfe; Richard J. Barohn; Barbara M. Foster; Carlayne E. Jackson; John T. Kissel; John W. Day; Charles A. Thornton; Sharon P. Nations; Wilson W. Bryan; Anthony A. Amato; Miriam L. Freimer; Gareth J. Parry

doi:10.1002/mus.10224

Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis

Gil I. Wolfe, Richard J. Barohn, Barbara M. Foster, Carlayne E. Jackson, John T. Kissel, John W. Day, Charles A. Thornton, Sharon P. Nations, Wilson W. Bryan, Anthony A. Amato, Miriam L. Freimer, Gareth J. Parry

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

We initiated a randomized, double-blinded, placebo-controlled trial of intravenous immunoglobulin (IVIG) treatment in myasthenia gravis (MG). Patients received IVIG 2 gm/kg at induction and 1 gm/kg after 3 weeks vs. 5% albumin placebo. The primary efficacy measurement was the change in the quantitative MG Score (QMG) at day 42. Fifteen patients were enrolled (6 to IVIG; 9 to placebo) before the study was terminated because of insufficient IVIG inventories. At day 42, there was no significant difference in primary or secondary outcome measurements between the two groups. In a subsequent 6-week open-label study of IVIG, positive trends were observed.

Original language	English (US)
Pages (from-to)	549-552
Number of pages	4
Journal	Muscle and Nerve
Volume	26
Issue number	4
DOIs	https://doi.org/10.1002/mus.10224
State	Published - Oct 1 2002

Keywords

Clinical trials
Intravenous immunoglobulin
Myasthenia gravis
Treatment

ASJC Scopus subject areas

Physiology
Clinical Neurology
Cellular and Molecular Neuroscience
Physiology (medical)

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10.1002/mus.10224

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title = "Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis",

abstract = "We initiated a randomized, double-blinded, placebo-controlled trial of intravenous immunoglobulin (IVIG) treatment in myasthenia gravis (MG). Patients received IVIG 2 gm/kg at induction and 1 gm/kg after 3 weeks vs. 5% albumin placebo. The primary efficacy measurement was the change in the quantitative MG Score (QMG) at day 42. Fifteen patients were enrolled (6 to IVIG; 9 to placebo) before the study was terminated because of insufficient IVIG inventories. At day 42, there was no significant difference in primary or secondary outcome measurements between the two groups. In a subsequent 6-week open-label study of IVIG, positive trends were observed.",

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AU - Wolfe, Gil I.

AU - Barohn, Richard J.

AU - Foster, Barbara M.

AU - Jackson, Carlayne E.

AU - Kissel, John T.

AU - Day, John W.

AU - Thornton, Charles A.

AU - Nations, Sharon P.

AU - Bryan, Wilson W.

AU - Amato, Anthony A.

AU - Freimer, Miriam L.

AU - Parry, Gareth J.

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AB - We initiated a randomized, double-blinded, placebo-controlled trial of intravenous immunoglobulin (IVIG) treatment in myasthenia gravis (MG). Patients received IVIG 2 gm/kg at induction and 1 gm/kg after 3 weeks vs. 5% albumin placebo. The primary efficacy measurement was the change in the quantitative MG Score (QMG) at day 42. Fifteen patients were enrolled (6 to IVIG; 9 to placebo) before the study was terminated because of insufficient IVIG inventories. At day 42, there was no significant difference in primary or secondary outcome measurements between the two groups. In a subsequent 6-week open-label study of IVIG, positive trends were observed.

KW - Clinical trials

KW - Intravenous immunoglobulin

KW - Myasthenia gravis

KW - Treatment

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Randomized, controlled trial of intravenous immunoglobulin in myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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