Randomized investigation of antimicrobials for the prevention of preterm birth

S. M. Cox, V. R. Bohman, M. L. Sherman, K. J. Leveno

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

OBJECTIVE: Occult amniotic fluid infection has emerged as a possible cause of many heretofore unexplained preterm births. We sought to determine whether antimicrobial therapy is effective in preventing preterm delivery. STUDY DESIGN: A double-blind, placebo-controlled, randomized trial was conducted to study the efficacy of ampicillin-sulbactam and amoxicillin-clavulanic acid in women hospitalized for preterm labor between 24 and 34 weeks' gestation. During this investigation no tocolytics or steroids were used. RESULTS: Thirty-nine women with preterm labor received antimicrobial therapy and 39 received placebos. The mean gestational ages at study entry were 29.8 ± 0.4 weeks (SEM) and 30.6 ± 0.3 weeks in the antimicrobial and placebo groups, respectively (not significant). Similarly, the mean gestational ages at delivery were 34.2 ± 0.7 and 34.1 ± 0.6 weeks, respectively (not significant). Other index values of pregnancy outcome, for example, birth weight, neonatal morbidity, and prenatal death, were not significantly improved by antimicrobial therapy given to the mother in preterm labor. CONCLUSION: We find that antimicrobial therapy given to women in preterm labor is ineffective in the prevention of preterm birth.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume174
Issue number1
DOIs
StatePublished - 1996

Fingerprint

Premature Obstetric Labor
Premature Birth
Placebos
Gestational Age
Tocolytic Agents
Amoxicillin-Potassium Clavulanate Combination
Amniotic Fluid
Therapeutics
Pregnancy Outcome
Birth Weight
Randomized Controlled Trials
Steroids
Mothers
Morbidity
Pregnancy
Infection

Keywords

  • antimicrobials
  • intact fetal membranes
  • Preterm birth

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Randomized investigation of antimicrobials for the prevention of preterm birth. / Cox, S. M.; Bohman, V. R.; Sherman, M. L.; Leveno, K. J.

In: American Journal of Obstetrics and Gynecology, Vol. 174, No. 1, 1996, p. 206-210.

Research output: Contribution to journalArticle

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