Ranitidine and recurrent hemorrhage from duodenal ulcer

R. J L F Loffeld, A. B M M Van der Putten, D. M. Jensen, W. L. Peterson

Research output: Contribution to journalLetterpeer-review

6 Scopus citations


To the Editor: Jensen et al. (Feb. 10 issue)1 showed that recurrent bleeding of duodenal ulcers can be prevented to a large extent by instituting maintenance therapy with histamine H-receptor blockers. Since the authors excluded all patients who were using ulcerogenic drugs, it is likely that almost all the patients had helicobacter-associated duodenal ulcers. Unfortunately, the developments in research on Helicobacter pylori already outdate the results and conclusions of this study. There is overwhelming scientific evidence that H. pylori is the most important factor in duodenal ulcer disease, especially with respect to relapse2. After successful eradication with triple therapy.

Original languageEnglish (US)
Pages (from-to)53-54
Number of pages2
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jul 7 1994

ASJC Scopus subject areas

  • Medicine(all)


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