RANTES deficiency attenuates autoantibody-induced glomerulonephritis

Chun Xie, Kui Liu, Yuyang Fu, Xiangmei Qin, Geetha Jonnala, Tao Wang, Hong W. Wang, Michael Maldonado, Xin J. Zhou, Chandra Mohan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Experimental autoimmune nephritis in mice and spontaneous lupus nephritis are both associated with elevated expression of several chemokines in the kidneys. Nevertheless, the role that different chemokines play in mediating renal inflammation is far from complete. This study focuses on elucidating the functional role of RANTES, a chemokine that has been noted to be hyper-expressed within the kidneys, both in experimental renal disease as well as in spontaneous lupus nephritis. To elucidate if RANTES was essential for immune-mediated glomerulonephritis, DBA/1 mice that are highly sensitive to nephrotoxic serum nephritis were rendered RANTES-deficient and then tested for disease susceptibility. Nephritis-sensitive DBA/1 mice expressed more RANTES within the diseased kidneys. Compared to wild-type DBA/1 mice, RANTES-deficient DBA/1 mice developed significantly less proteinuria, azotemia, and renal inflammation, with reduced crescent formation and tubulo-interstitial nephritis. These findings indicate that RANTES ablation attenuates immune-mediated nephritis and suggest that this chemokine could be a potential therapeutic target in these diseases.

Original languageEnglish (US)
Pages (from-to)128-135
Number of pages8
JournalJournal of Clinical Immunology
Volume31
Issue number1
DOIs
StatePublished - Feb 1 2011

Keywords

  • DBA/1
  • RANTES
  • genetics
  • lupus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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