Rapid High-resolution, Self-registered, Dual Lumen-contrast MRI Method for Vessel-wall Assessment in Peripheral Artery Disease

A Preliminary Investigation

Michael C. Langham, Benoit Desjardins, Erin K. Englund, Emile R. Mohler, Thomas F. Floyd, Felix W. Wehrli

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rationale and Objectives: Contrast-enhanced angiographic evaluation by magnetic resonance imaging (MRI) and computed tomography (CT) is the reference standard for assessing peripheral artery disease (PAD). However, because PAD and diabetes often coexist, the prevalence of renal insufficiency is a major challenge to contrast-based angiography. The objective of this work is to describe and demonstrate a new application of three-dimensional double-echo steady-state (3D DESS) as a noncontrast vascular MRI method for evaluating peripheral atherosclerosis at 3 Tesla (3T). Materials and Methods: A water-selective 3D DESS pulse sequence was designed to simultaneously collect two steady-state free-precession signals (free induction decay and Echo) yielding "black blood" (BB) and "gray blood" (GB) images. For completeness Bloch equation, simulations were performed to characterize DESS signals of various tissues including blood at different velocities and to assess two healthy subjects for the purpose of pulse sequence optimization. Exploratory studies were performed as an add-on protocol to an existing study involving patients with PAD. To evaluate the method's specificity for detecting calcification, images from select patients were compared against CT angiography. Results: Simulations agreed qualitatively with in vivo images supporting DESS' potential for generating distinct lumen contrast (GB vs BB). Lesions representing calcium were easily identifiable on the basis of signal void occurring on both image types and were confirmed by CT angiography. Further, BB allowed visualization of stent restenosis, and data suggest its ability to visualize acute thrombus by virtue of T2 weighting. Conclusion: Preliminary investigation and results suggest noncontrast 3D DESS to have the potential to improve diagnosis of PAD patients by providing detailed structural assessment of vessel-wall architecture.

Original languageEnglish (US)
Pages (from-to)457-467
Number of pages11
JournalAcademic Radiology
Volume23
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Peripheral Arterial Disease
Magnetic Resonance Imaging
Stents
Renal Insufficiency
Blood Vessels
Atherosclerosis
Healthy Volunteers
Angiography
Thrombosis
Tomography
Calcium
Water

Keywords

  • Angiography
  • Black-blood imaging
  • Calcification
  • Double-echo steady-state
  • Gray-blood imaging
  • Peripheral artery disease
  • SSFP-Echo
  • SSFP-FID
  • Vessel-wall imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Rapid High-resolution, Self-registered, Dual Lumen-contrast MRI Method for Vessel-wall Assessment in Peripheral Artery Disease : A Preliminary Investigation. / Langham, Michael C.; Desjardins, Benoit; Englund, Erin K.; Mohler, Emile R.; Floyd, Thomas F.; Wehrli, Felix W.

In: Academic Radiology, Vol. 23, No. 4, 01.04.2016, p. 457-467.

Research output: Contribution to journalArticle

Langham, Michael C. ; Desjardins, Benoit ; Englund, Erin K. ; Mohler, Emile R. ; Floyd, Thomas F. ; Wehrli, Felix W. / Rapid High-resolution, Self-registered, Dual Lumen-contrast MRI Method for Vessel-wall Assessment in Peripheral Artery Disease : A Preliminary Investigation. In: Academic Radiology. 2016 ; Vol. 23, No. 4. pp. 457-467.
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