Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography

Yong Du, Chih Hao Liu, Ling Lei, Manmohan Singh, Jiasong Li, M. John Hicks, Kirill V. Larin, Chandra Mohan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p

Original languageEnglish (US)
Article number046002
JournalJournal of Biomedical Optics
Volume21
Issue number4
DOIs
StatePublished - Apr 30 2016

Fingerprint

Skin
connective tissue
collagens
organs
micrometers
emerging
modulus of elasticity
elastic properties
spatial resolution
mechanical properties
Bleomycin
Tissue
Collagen
Elasticity
Elastic moduli
Mechanical properties

Keywords

  • dermatology
  • elastic wave velocity
  • elasticity
  • optical coherence elastography
  • scleroderma

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography. / Du, Yong; Liu, Chih Hao; Lei, Ling; Singh, Manmohan; Li, Jiasong; Hicks, M. John; Larin, Kirill V.; Mohan, Chandra.

In: Journal of Biomedical Optics, Vol. 21, No. 4, 046002, 30.04.2016.

Research output: Contribution to journalArticle

Du, Yong ; Liu, Chih Hao ; Lei, Ling ; Singh, Manmohan ; Li, Jiasong ; Hicks, M. John ; Larin, Kirill V. ; Mohan, Chandra. / Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography. In: Journal of Biomedical Optics. 2016 ; Vol. 21, No. 4.
@article{9b6de412adf647d398fd74c2d7990502,
title = "Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography",
abstract = "Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55{\%}. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p",
keywords = "dermatology, elastic wave velocity, elasticity, optical coherence elastography, scleroderma",
author = "Yong Du and Liu, {Chih Hao} and Ling Lei and Manmohan Singh and Jiasong Li and Hicks, {M. John} and Larin, {Kirill V.} and Chandra Mohan",
year = "2016",
month = "4",
day = "30",
doi = "10.1117/1.JBO.21.4.046002",
language = "English (US)",
volume = "21",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "4",

}

TY - JOUR

T1 - Rapid, noninvasive quantitation of skin disease in systemic sclerosis using optical coherence elastography

AU - Du, Yong

AU - Liu, Chih Hao

AU - Lei, Ling

AU - Singh, Manmohan

AU - Li, Jiasong

AU - Hicks, M. John

AU - Larin, Kirill V.

AU - Mohan, Chandra

PY - 2016/4/30

Y1 - 2016/4/30

N2 - Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p

AB - Systemic sclerosis (SSc) is a connective tissue disease that results in excessive accumulation of collagen in the skin and internal organs. Overall, SSc has a rare morbidity (276 cases per million adults in the United States), but has a 10-year survival rate of 55%. Currently, the modified Rodnan skin score (mRSS) is assessed by palpation on 17 sites on the body. However, the mRSS assessed score is subjective and may be influenced by the experience of the rheumatologists. In addition, the inherent elasticity of skin may bias the mRSS assessment in the early stage of SSc, such as oedematous. Optical coherence elastography (OCE) is a rapidly emerging technique, which can assess mechanical contrast in tissues with micrometer spatial resolution. In this work, the OCE technique is applied to assess the mechanical properties of skin in both control and bleomycin (BLM) induced SSc-like disease noninvasively. Young's modulus of the BLM-SSc skin was found be significantly higher than that of normal skin, in both the in vivo and in vitro studies (p

KW - dermatology

KW - elastic wave velocity

KW - elasticity

KW - optical coherence elastography

KW - scleroderma

UR - http://www.scopus.com/inward/record.url?scp=84964455483&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964455483&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.21.4.046002

DO - 10.1117/1.JBO.21.4.046002

M3 - Article

VL - 21

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 4

M1 - 046002

ER -