Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor

Neel Dixit, Adam Castano, Mary Jane Farr, Rebecca Traub, Suzanne Lentzsch, Robert S. Brown, Mathew S. Maurer, Thomas H. Brannagan

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalJournal of Clinical Neuromuscular Disease
Volume17
Issue number3
DOIs
StatePublished - 2016
Externally publishedYes

Keywords

  • Cardiomyopathy
  • Polyneuropathy
  • Systemic amyloidosis
  • TC-pyrophosphate scan
  • TTR gene

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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