Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor

Neel Dixit; Adam Castano; Mary Jane Farr; Rebecca Traub; Suzanne Lentzsch; Robert S. Brown; Mathew S. Maurer; Thomas H. Brannagan

doi:10.1097/CND.0000000000000110

Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor

Neel Dixit, Adam Castano, Mary Jane Farr, Rebecca Traub, Suzanne Lentzsch, Robert S. Brown, Mathew S. Maurer, Thomas H. Brannagan

Research output: Contribution to journal › Review article › peer-review

8 Scopus citations

Abstract

Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.

Original language	English (US)
Pages (from-to)	142-145
Number of pages	4
Journal	Journal of Clinical Neuromuscular Disease
Volume	17
Issue number	3
DOIs	https://doi.org/10.1097/CND.0000000000000110
State	Published - 2016
Externally published	Yes

Keywords

Cardiomyopathy
Polyneuropathy
Systemic amyloidosis
TC-pyrophosphate scan
TTR gene

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor",

abstract = "Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.",

keywords = "Cardiomyopathy, Polyneuropathy, Systemic amyloidosis, TC-pyrophosphate scan, TTR gene",

author = "Neel Dixit and Adam Castano and Farr, {Mary Jane} and Rebecca Traub and Suzanne Lentzsch and Brown, {Robert S.} and Maurer, {Mathew S.} and Brannagan, {Thomas H.}",

year = "2016",

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language = "English (US)",

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pages = "142--145",

journal = "Journal of Clinical Neuromuscular Disease",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor

AU - Dixit, Neel

AU - Castano, Adam

AU - Farr, Mary Jane

AU - Traub, Rebecca

AU - Lentzsch, Suzanne

AU - Brown, Robert S.

AU - Maurer, Mathew S.

AU - Brannagan, Thomas H.

PY - 2016

Y1 - 2016

N2 - Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.

AB - Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation.

KW - Cardiomyopathy

KW - Polyneuropathy

KW - Systemic amyloidosis

KW - TC-pyrophosphate scan

KW - TTR gene

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AN - SCOPUS:84959931614

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Rapidly progressive transthyretin-mediated amyloidosis in a domino liver transplant recipient of a Ser23Asn donor

Abstract

Keywords

ASJC Scopus subject areas

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