Ras and Nox: Linked signaling networks?

Ru Feng Wu; Lance S. Terada

doi:10.1016/j.freeradbiomed.2009.05.037

Ras and Nox: Linked signaling networks?

Ru Feng Wu, Lance S. Terada

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility, differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review, we examine the interface where these two large fields meet.

Original language	English (US)
Pages (from-to)	1276-1281
Number of pages	6
Journal	Free Radical Biology and Medicine
Volume	47
Issue number	9
DOIs	https://doi.org/10.1016/j.freeradbiomed.2009.05.037
State	Published - Nov 1 2009

Keywords

Apoptosis
MAPK
NADPH oxidase
Reactive oxidant species (ROS)
Signal transduction
Transformation

ASJC Scopus subject areas

Biochemistry
Physiology (medical)

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10.1016/j.freeradbiomed.2009.05.037

Cite this

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title = "Ras and Nox: Linked signaling networks?",

abstract = "Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility, differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review, we examine the interface where these two large fields meet.",

keywords = "Apoptosis, MAPK, NADPH oxidase, Reactive oxidant species (ROS), Signal transduction, Transformation",

author = "Wu, {Ru Feng} and Terada, {Lance S.}",

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AU - Terada, Lance S.

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AB - Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility, differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review, we examine the interface where these two large fields meet.

KW - Apoptosis

KW - MAPK

KW - NADPH oxidase

KW - Reactive oxidant species (ROS)

KW - Signal transduction

KW - Transformation

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JO - Free Radical Biology and Medicine

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IS - 9

ER -

Ras and Nox: Linked signaling networks?

Abstract

Keywords

ASJC Scopus subject areas

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