Ras and Nox: Linked signaling networks?

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17 Scopus citations

Abstract

Both Ras and Nox represent ancient gene families which control a broad range of cellular responses. Both families mediate signals governing motility, differentiation, and proliferation, and both inhabit overlapping subcellular microdomains. Yet little is known of the precise functional relationship between these two ubiquitous families. In this review, we examine the interface where these two large fields meet.

Original languageEnglish (US)
Pages (from-to)1276-1281
Number of pages6
JournalFree Radical Biology and Medicine
Volume47
Issue number9
DOIs
Publication statusPublished - Nov 1 2009

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Keywords

  • Apoptosis
  • MAPK
  • NADPH oxidase
  • Reactive oxidant species (ROS)
  • Signal transduction
  • Transformation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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